CBL neddylates TGFBR2

Stable Identifier
R-HSA-4332236
Type
Reaction [transition]
Species
Homo sapiens
Compartment
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CBL neddylates TGFBR2 on lysine residues K556 and K567. The E3 ubiquitin ligase activity of CBL is necessary for this modification, and the kinase activity of TGFBR2 is also required. CBL-mediated neddylation prolongs the half-life of TGFBR2, thereby enhancing signaling by the TGF-beta receptor complex. CBLB, a CBL-related protein, may cooperate with CBL in TGFBR2 neddylation (Zuo et al. 2013).

Literature References
PubMed ID Title Journal Year
23290524 c-Cbl-mediated neddylation antagonizes ubiquitination and degradation of the TGF-? type II receptor

Zuo, W, Huang, F, Chiang, YJ, Li, M, Du, J, Ding, Y, Zhang, T, Lee, HW, Jeong, LS, Chen, Y, Deng, H, Feng, XH, Luo, S, Gao, C, Chen, YG

Mol. Cell 2013
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
ubiquitin-protein transferase activity of TGFBR2:CBL [plasma membrane]
Physical Entity
Activity
Orthologous Events
Authored
Reviewed
Created