CBL binds TGFBR2

Stable Identifier
R-HSA-4332235
Type
Reaction [binding]
Species
Homo sapiens
Compartment
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The E3 ubiquitin ligase CBL binds the cytoplasmic tail of plasma membrane-bound TGFBR2 (TGF-beta receptor 2) but not TGFBR1 (TGF-beta receptor 1). The tyrosine kinase binding (TKB) domain of CBL is involved in this interaction (Zuo et al. 2013).

Literature References
PubMed ID Title Journal Year
23290524 c-Cbl-mediated neddylation antagonizes ubiquitination and degradation of the TGF-? type II receptor

Zuo, W, Huang, F, Chiang, YJ, Li, M, Du, J, Ding, Y, Zhang, T, Lee, HW, Jeong, LS, Chen, Y, Deng, H, Feng, XH, Luo, S, Gao, C, Chen, YG

Mol. Cell 2013
Participants
Participant Of
Orthologous Events
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Created