NaDC1 co-transports dicarboxylic acids and a sodium ion

Stable Identifier
R-HSA-433131
Type
Reaction [transition]
Species
Homo sapiens
Compartment
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Mammalian sodium/dicarboxylate cotransporters (transport succinate and other Krebs cycle intermediates) fall into two categories based on their substrate affinity. The human gene SLC13A2 encodes a low-affinity sodium/dicarboxlate co-transporter, NaDC1. NaDC1 is highly expressed in the brush-border membranes of kidney and intestinal cells and reabsorbs Krebs cycle intermediates, such as succinate and citrate, from the glomerular filtrate (Pajor AM, 1996).

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Catalyst Activity
Title
low-affinity sodium:dicarboxylate symporter activity of SLC13A2 [plasma membrane]
Physical Entity
Activity
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