NaDC1 co-transports dicarboxylic acids and a sodium ion

Stable Identifier
R-HSA-433131
Type
Reaction [transition]
Species
Homo sapiens
Compartment
plasma membrane
ReviewStatus
5/5
Locations in the PathwayBrowser
Expand all
General
SVG | 
PNG
Low
Medium
High
 | PPTX  | SBGN
NaDC1 co-transports dicarboxylic acids and a sodium ion
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout
Mammalian sodium/dicarboxylate cotransporters (transport succinate and other Krebs cycle intermediates) fall into two categories based on their substrate affinity. The human gene SLC13A2 encodes a low-affinity sodium/dicarboxlate co-transporter, NaDC1. NaDC1 is highly expressed in the brush-border membranes of kidney and intestinal cells and reabsorbs Krebs cycle intermediates, such as succinate and citrate, from the glomerular filtrate (Pajor AM, 1996).
Literature References
Participants
Input
Output
Participates
as an event of
Catalyst Activity

low-affinity sodium:dicarboxylate symporter activity of SLC13A2 [plasma membrane]

Physical Entity
SLC13A2 [plasma membrane] (Homo sapiens)
Activity
low-affinity sodium:dicarboxylate symporter activity (GO:0015361)
Orthologous Events
NaDC1 co-transports dicarboxylic acids and a sodium ion (Bos taurus)
NaDC1 co-transports dicarboxylic acids and a sodium ion (Caenorhabditis elegans)
NaDC1 co-transports dicarboxylic acids and a sodium ion (Canis familiaris)
NaDC1 co-transports dicarboxylic acids and a sodium ion (Danio rerio)
NaDC1 co-transports dicarboxylic acids and a sodium ion (Drosophila melanogaster)
NaDC1 co-transports dicarboxylic acids and a sodium ion (Gallus gallus)
NaDC1 co-transports dicarboxylic acids and a sodium ion (Mus musculus)
NaDC1 co-transports dicarboxylic acids and a sodium ion (Rattus norvegicus)
NaDC1 co-transports dicarboxylic acids and a sodium ion (Sus scrofa)
NaDC1 co-transports dicarboxylic acids and a sodium ion (Xenopus tropicalis)
Authored
Jassal, B  (2009-08-21)
Reviewed
He, L  (2009-11-12)
Created
Jassal, B  (2009-08-21)
Cite Us!