NaDC3 co-transports the dicarboxylic acid succinate and three sodium ion

Stable Identifier
R-HSA-433101
Type
Reaction [transition]
Species
Homo sapiens
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Mammalian sodium/dicarboxylate cotransporters (transport succinate and other Krebs cycle intermediates) fall into two categories based on their substrate affinity. The human gene SLC13A3 encodes a high-affinity sodium/dicarboxlate co-transporter, NaDC3. NaDC3 is expressed in the basolateral membrane of renal proximal tubular epithelial cells, sinusoidal membrane of hepatocytes, and brain synaptosomes. Kinetic studies in human retinal pigment epithelial (HRPE) cells suggest three sodium ions co-transported with every divalent succinate (Wang H et al, 2000).

Literature References
PubMed ID Title Journal Year
10794676 Structure, function, and genomic organization of human Na(+)-dependent high-affinity dicarboxylate transporter

Wang, H, Fei, YJ, Kekuda, R, Yang-Feng, TL, Devoe, LD, Leibach, FH, Prasad, PD, Ganapathy, V

Am J Physiol Cell Physiol 2000
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Catalyst Activity
Title
high-affinity sodium:dicarboxylate symporter activity of SLC13A3 [plasma membrane]
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