Reactome | NaDC3 co-transports the dicarboxylic acid succinate and three sodium ion

NaDC3 co-transports the dicarboxylic acid succinate and three sodium ion

Stable Identifier

R-HSA-433101

Type

Reaction [transition]

Species

Homo sapiens

Compartment

plasma membrane

ReviewStatus

5/5

Locations in the PathwayBrowser

Expand all

General

SBML | | PDF

SVG | | PPTX | SBGN

NaDC3 co-transports the dicarboxylic acid succinate and three sodium ion

Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

Mammalian sodium/dicarboxylate cotransporters (transport succinate and other Krebs cycle intermediates) fall into two categories based on their substrate affinity. The human gene SLC13A3 encodes a high-affinity sodium/dicarboxlate co-transporter, NaDC3. NaDC3 is expressed in the basolateral membrane of renal proximal tubular epithelial cells, sinusoidal membrane of hepatocytes, and brain synaptosomes. Kinetic studies in human retinal pigment epithelial (HRPE) cells suggest three sodium ions co-transported with every divalent succinate (Wang H et al, 2000).

Literature References

PubMed ID	Title	Journal	Year
10794676	Structure, function, and genomic organization of human Na(+)-dependent high-affinity dicarboxylate transporter Leibach, FH, Ganapathy, V, Yang-Feng, TL, Devoe, LD, Prasad, PD, Kekuda, R, Fei, YJ, Wang, H	Am J Physiol Cell Physiol	2000