Reactome | AVP:AVPR2:heterotrimeric G(s) complex exchanges GDP for GTP

AVP:AVPR2:heterotrimeric G(s) complex exchanges GDP for GTP

Stable Identifier

R-HSA-432195

Type

Reaction [transition]

Species

Homo sapiens

Compartment

plasma membrane, cytosol

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AVP:AVPR2:heterotrimeric G(s) complex exchanges GDP for GTP

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The AVP:AVPR2 complex activates G-protein alpha s by causing a conformational change in G-protein alpha s that causes it to release GDP and bind GTP.

Literature References

PubMed ID	Title	Journal	Year
11968001	S111N mutation in the helical domain of human Gs(alpha) reduces its GDP/GTP exchange rate Brito, M, Guzmán, L, Romo, X, Soto, X, Hinrichs, MV, Olate, J	J Cell Biochem	2002
10649434	Mutagenesis in the switch IV of the helical domain of the human Gsalpha reduces its GDP/GTP exchange rate Echeverria, V, Hinrichs, MV, Torrejón, M, Ropero, S, Martinez, J, Toro, MJ, Olate, J	J Cell Biochem	2000