Reactome | AVP:AVPR2:heterotrimeric G(s) complex exchanges GDP for GTP

AVP:AVPR2:heterotrimeric G(s) complex exchanges GDP for GTP

Stable Identifier

R-HSA-432195

Type

Reaction [transition]

Species

Homo sapiens

Compartment

plasma membrane, cytosol

ReviewStatus

5/5

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AVP:AVPR2:heterotrimeric G(s) complex exchanges GDP for GTP

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The AVP:AVPR2 complex activates G-protein alpha s by causing a conformational change in G-protein alpha s that causes it to release GDP and bind GTP.

Literature References

PubMed ID	Title	Journal	Year
10649434	Mutagenesis in the switch IV of the helical domain of the human Gsalpha reduces its GDP/GTP exchange rate Echeverria, V, Hinrichs, MV, Torrejón, M, Ropero, S, Martinez, J, Toro, MJ, Olate, J	J Cell Biochem	2000
11968001	S111N mutation in the helical domain of human Gs(alpha) reduces its GDP/GTP exchange rate Brito, M, Guzmán, L, Romo, X, Soto, X, Hinrichs, MV, Olate, J	J Cell Biochem	2002