Reactome | Fgr may phosphorylate p38 MAPK

Fgr may phosphorylate p38 MAPK

Stable Identifier

R-HSA-432148

Type

Reaction [omitted]

Species

Homo sapiens

Compartment

cytosol

ReviewStatus

5/5

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LDL stimulation of platelets leads to increased p38 MAPK activation by phosphorylation. An Src family kinase is responsible for this; Fgr is a strong candidate as it is known to bind the LDL receptor in platelets responding to LDL and in chemoattractant-induced degranulation of neutrophils activation of p38 MAPK is blocked by a triple Hck/Fgr/Lyn knockout. However fMLP-stimulated phosphorylation of MAPKs in a double hck/fgr PMNs was observed to be normal, suggesting that Lyn, rather than Fyn, is involved.

Literature References

PubMed ID	Title	Journal	Year
17339487	The Src family kinases Hck and Fgr regulate neutrophil responses to N-formyl-methionyl-leucyl-phenylalanine Fumagalli, L, Zhang, H, Baruzzi, A, Lowell, CA, Berton, G	J Immunol	2007
10754332	Kinase pathways in chemoattractant-induced degranulation of neutrophils: the role of p38 mitogen-activated protein kinase activated by Src family kinases Mocsai, A, Jakus, Z, Vántus, T, Berton, G, Lowell, CA, Ligeti, E	J Immunol	2000