Fgr may phosphorylate p38 MAPK

Stable Identifier
R-HSA-432148
Type
Reaction [omitted]
Species
Homo sapiens
Compartment
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LDL stimulation of platelets leads to increased p38 MAPK activation by phosphorylation. An Src family kinase is responsible for this; Fgr is a strong candidate as it is known to bind the LDL receptor in platelets responding to LDL and in chemoattractant-induced degranulation of neutrophils activation of p38 MAPK is blocked by a triple Hck/Fgr/Lyn knockout. However fMLP-stimulated phosphorylation of MAPKs in a double hck/fgr PMNs was observed to be normal, suggesting that Lyn, rather than Fyn, is involved.

Literature References
PubMed ID Title Journal Year
10754332 Kinase pathways in chemoattractant-induced degranulation of neutrophils: the role of p38 mitogen-activated protein kinase activated by Src family kinases

Mocsai, A, Jakus, Z, VĂ¡ntus, T, Berton, G, Lowell, CA, Ligeti, E

J Immunol 2000
17339487 The Src family kinases Hck and Fgr regulate neutrophil responses to N-formyl-methionyl-leucyl-phenylalanine

Fumagalli, L, Zhang, H, Baruzzi, A, Lowell, CA, Berton, G

J Immunol 2007
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
non-membrane spanning protein tyrosine kinase activity of FGR [cytosol]
Physical Entity
Activity
Orthologous Events
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Created