Fgr may phosphorylate p38 MAPK

Stable Identifier
Reaction [BlackBoxEvent]
Homo sapiens
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LDL stimulation of platelets leads to increased p38 MAPK activation by phosphorylation. An Src family kinase is responsible for this; Fgr is a strong candidate as it is known to bind the LDL receptor in platelets responding to LDL and in chemoattractant-induced degranulation of neutrophils activation of p38 MAPK is blocked by a triple Hck/Fgr/Lyn knockout. However fMLP-stimulated phosphorylation of MAPKs in a double hck/fgr PMNs was observed to be normal, suggesting that Lyn, rather than Fyn, is involved.

Literature References
PubMed ID Title Journal Year
17339487 The Src family kinases Hck and Fgr regulate neutrophil responses to N-formyl-methionyl-leucyl-phenylalanine

Lowell, CA, Baruzzi, A, Zhang, H, Fumagalli, L, Berton, G

J Immunol 2007
10754332 Kinase pathways in chemoattractant-induced degranulation of neutrophils: the role of p38 mitogen-activated protein kinase activated by Src family kinases

Lowell, CA, Mocsai, A, Ligeti, E, Jakus, Z, VĂ¡ntus, T, Berton, G

J Immunol 2000
Catalyst Activity

non-membrane spanning protein tyrosine kinase activity of FGR [cytosol]

Orthologous Events
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