LDL stimulation of platelets leads to increased p38 MAPK activation by phosphorylation. An Src family kinase is responsible for this; Fgr is a strong candidate as it is known to bind the LDL receptor in platelets responding to LDL and in chemoattractant-induced degranulation of neutrophils activation of p38 MAPK is blocked by a triple Hck/Fgr/Lyn knockout. However fMLP-stimulated phosphorylation of MAPKs in a double hck/fgr PMNs was observed to be normal, suggesting that Lyn, rather than Fyn, is involved.
Lowell, CA, Baruzzi, A, Zhang, H, Fumagalli, L, Berton, G
Lowell, CA, Mocsai, A, Ligeti, E, Jakus, Z, Vántus, T, Berton, G
non-membrane spanning protein tyrosine kinase activity of FGR [cytosol]
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