LPR8 (apoER2) is the platelet low density lipoprotein (LDL) receptor. Mice lacking ApoE develop hypercholesterolemia and later atherosclerosis (Zhang et al. 1992). Similiar results are seen in familial hypercholesterolemia, where defective apoB/E receptors fail to remove LDL from the circulation.
Akkerman, JW, Gorter, G, Korporaal, SJ, Strasser, V, Lenting, PJ, Bezemer, M, Nimpf, J, van Eck, M, Relou, IA, van Berkel, TJ
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