LDL binds to LRP8

Stable Identifier
R-HSA-432121
Type
Reaction [binding]
Species
Homo sapiens
Compartment
extracellular region, plasma membrane
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LDL binds to LRP8
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LPR8 (apoER2) is the platelet low density lipoprotein (LDL) receptor. Mice lacking ApoE develop hypercholesterolemia and later atherosclerosis (Zhang et al. 1992). Similiar results are seen in familial hypercholesterolemia, where defective apoB/E receptors fail to remove LDL from the circulation.

Literature References
PubMed ID Title Journal Year
15459198 Binding of low density lipoprotein to platelet apolipoprotein E receptor 2' results in phosphorylation of p38MAPK

Korporaal, SJ, Relou, IA, van Eck, M, Strasser, V, Bezemer, M, Gorter, G, van Berkel, TJ, Nimpf, J, Akkerman, JW, Lenting, PJ

J Biol Chem 2004
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Authored
Akkerman, JW  (2009-09-04)
Reviewed
Kunapuli, SP  (2010-06-07)
Created
Jupe, S  (2009-08-11)