Reactome | p-S256-Aquaporin-2 passively transports water into cell

p-S256-Aquaporin-2 passively transports water into cell

Stable Identifier

R-HSA-432065

Type

Reaction [transition]

Species

Homo sapiens

Compartment

plasma membrane, cytosol, extracellular region

ReviewStatus

5/5

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p-S256-Aquaporin-2 passively transports water into cell

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Aquaporin-2 (AQP2) passively transports water across membranes according to the osmotic gradient. AQP2 is mainly expressed in principal cells of the collecting duct and connecting tubule in the kidney. AQP2 function is acutely regulated by the antidiuretc hormone vasopressin. In the presence of vasopressin AQP is phosphorylated at Ser256, As inferred from rat and mouse Ser261, Ser264, and Thr269 may also be phosphorylated. These phosphorylations are thought to influence AQP2 trafficking and compartmentalization.

Literature References

PubMed ID	Title	Journal	Year
11076974	The subcellular localization of an aquaporin-2 tetramer depends on the stoichiometry of phosphorylated and nonphosphorylated monomers van Os, CH, Deen, PM, Kamsteeg, EJ, Heijnen, I	J Cell Biol	2000
7510718	Cloning, characterization, and chromosomal mapping of human aquaporin of collecting duct Nakajima, K, Saito, H, Kuwahara, M, Ishibashi, K, Saito, F, Inui, K, Uchida, S, Ikeuchi, T, Sasaki, S, Fushimi, K	J Clin Invest	1994
19144687	Role of multiple phosphorylation sites in the COOH-terminal tail of aquaporin-2 for water transport: evidence against channel gating Fenton, RA, MacAulay, N, Moeller, HB, Knepper, MA	Am J Physiol Renal Physiol	2009
9829975	Bidirectional water fluxes and specificity for small hydrophilic molecules in aquaporins 0-5 Meinild, AK, Zeuthen, T, Klaerke, DA	J Biol Chem	1998
8140421	Requirement of human renal water channel aquaporin-2 for vasopressin-dependent concentration of urine van Os, CH, Deen, PM, Wieringa, B, Knoers, NV, van Oost, BA, Verdijk, MA, Monnens, LA	Science	1994
7535000	Water channel expression in human ADPKD kidneys Perrone, RD, Bachinsky, DR, Emmanouel, DS, Jefferson, DM, Sabolic, I, Brown, D, Carone, FA	Am J Physiol	1995
15703994	Distribution of AQP2 and AQP3 water channels in human tissue microarrays Marples, D, Wray, S, Mobasheri, A	J Mol Histol	2005