Aquaporin-1 passively transports water into cell

Stable Identifier
R-HSA-432010
Type
Reaction [transition]
Species
Homo sapiens
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Aquaporin-1 (AQP1) passively transports water across the plasma membrane according to the osmotic gradient. In the kidney AQP1 is expressed in endothelial cells of the vasa recta, the proximal tubule, and thin descending limb of Henle, where it functions to recover water from filtrate during urine formation. AQP1 is expressed in many other tissues, such as red blood cells, pancreas, and choroid plexus. AQP1 plays a role in forming cerebrospinal fluid.

Literature References
PubMed ID Title Journal Year
14701836 Aquaporin-1, nothing but a water channel

Tsunoda, SP, Wiesner, B, Lorenz, D, Rosenthal, W, Pohl, P

J Biol Chem 2004
3049610 Identification, purification, and partial characterization of a novel Mr 28,000 integral membrane protein from erythrocytes and renal tubules

Denker, BM, Smith, BL, Kuhajda, FP, Agre, P

J Biol Chem 1988
7678419 CHIP28 water channels are localized in constitutively water-permeable segments of the nephron

Nielsen, S, Smith, BL, Christensen, EI, Knepper, MA, Agre, P

J Cell Biol 1993
18202181 Mechanism of selectivity in aquaporins and aquaglyceroporins

Hub, JS, de Groot, BL

Proc Natl Acad Sci U S A 2008
12801959 Distribution of aquaporin water channels AQP1 and AQP5 in the ductal system of the human pancreas

Burghardt, B, Elkaer, ML, Kwon, TH, Rácz, GZ, Varga, G, Steward, MC, Nielsen, S

Gut 2003
1510932 Reconstitution of functional water channels in liposomes containing purified red cell CHIP28 protein

Zeidel, ML, Ambudkar, SV, Smith, BL, Agre, P

Biochemistry 1992
9829975 Bidirectional water fluxes and specificity for small hydrophilic molecules in aquaporins 0-5

Meinild, AK, Klaerke, DA, Zeuthen, T

J Biol Chem 1998
16407156 Point mutations in the aromatic/arginine region in aquaporin 1 allow passage of urea, glycerol, ammonia, and protons

Beitz, E, Wu, B, Holm, LM, Schultz, JE, Zeuthen, T

Proc Natl Acad Sci U S A 2006
11034202 Structural determinants of water permeation through aquaporin-1

Murata, K, Mitsuoka, K, Hirai, T, Walz, T, Agre, P, Heymann, JB, Engel, A, Fujiyoshi, Y

Nature 2000
14592814 Expression of the AQP-1 water channel in normal human tissues: a semiquantitative study using tissue microarray technology

Mobasheri, A, Marples, D

Am J Physiol Cell Physiol 2004
1373524 Appearance of water channels in Xenopus oocytes expressing red cell CHIP28 protein

Preston, GM, Carroll, TP, Guggino, WB, Agre, P

Science 1992
14514735 Aquaporin expression in normal human kidney and in renal disease

Bedford, JJ, Leader, JP, Walker, RJ

J Am Soc Nephrol 2003
19574955 Concerted action of two cation filters in the aquaporin water channel

Wu, B, Steinbronn, C, Alsterfjord, M, Zeuthen, T, Beitz, E

EMBO J 2009
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Event Information
Catalyst Activity
Catalyst Activity
Title
water channel activity of AQP1 tetramer [plasma membrane]
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Orthologous Events
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