MigFilin associates with Filamin and F-actin

Stable Identifier
R-HSA-430347
Type
Reaction [binding]
Species
Homo sapiens
Compartment
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Migfilin associates with actin filaments as a result of its interaction with filamin (Tu et al., 2003). Migfilin associates with actin filaments and loss of migfilin decreases the level of F-actin suggesting that, in addition to providing an anchoring site for actin filaments at cell-ECM adhesions, migfilin also functions in the regulation of filamin-mediated cross-linking and stabilization of actin filaments (Tu et al., 2003).

Literature References
PubMed ID Title Journal Year
12679033 Migfilin and Mig-2 link focal adhesions to filamin and the actin cytoskeleton and function in cell shape modulation

Tu, Y, Wu, S, Shi, X, Chen, K, Wu, C

Cell 2003
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