Rsu-1 interacts with Pinch1

Stable Identifier
R-HSA-430311
Type
Reaction
Species
Homo sapiens
Compartment
cytosol
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Summation

The Ras suppressor, Rsu-1, interacts with the LIM 5 domain of PINCH1 (but not PINCH2) and may inhibit cell migration by stabilizing the Pinch-ILK-parvin adhesion complex (Dougherty et al., 2008; Kadrmas et al., 2004).

Literature References
PubMed ID Title Journal Year
18436335 The Rsu-1-PINCH1-ILK complex is regulated by Ras activation in tumor cells

Dougherty, GW, Jose, C, Gimona, M, Cutler, ML

Eur J Cell Biol 2008
Participants
Input
Output
Participant Of
hasEvent
Orthologous Events
Rsu-1 interacts with Pinch1 (Caenorhabditis elegans)
Rsu-1 interacts with Pinch1 (Canis familiaris)
Rsu-1 interacts with Pinch1 (Danio rerio)
Rsu-1 interacts with Pinch1 (Drosophila melanogaster)
Rsu-1 interacts with Pinch1 (Gallus gallus)
Rsu-1 interacts with Pinch1 (Mus musculus)
Rsu-1 interacts with Pinch1 (Rattus norvegicus)
Rsu-1 interacts with Pinch1 (Taeniopygia guttata)
Rsu-1 interacts with Pinch1 (Xenopus tropicalis)
Authored
Matthews, L  (2009-10-12)
Reviewed
Wu, C  (2009-11-12)
Created
Matthews, L  (2009-08-06)