Reactome | PARVB interacts with Alpha-actinin

PARVB interacts with Alpha-actinin

Stable Identifier

R-HSA-430308

Type

Reaction [binding]

Species

Homo sapiens

Compartment

cytosol

ReviewStatus

5/5

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PARVB interacts with the actin cross-linking protein Alpha-actinin (Yamaji et al. 2004). The ILK-PARVB complex may serve as an integrin-anchoring site for alpha-actinin and thereby mediate integrin signaling to alpha-actinin, which has been shown to play an important role in actin polymerization at focal adhesions (Yamaji et al., 2004).

Literature References

PubMed ID	Title	Journal	Year
15159419	Affixin interacts with alpha-actinin and mediates integrin signaling for reorganization of F-actin induced by initial cell-substrate interaction Fujisawa, S, Kanamori, H, Ohno, S, Takasaki, H, Yamaji, S, Ishigatsubo, Y, Takabayashi, M, Yoshimi, R, Mishima, W, Fujimaki, K, Suzuki, A	J Cell Biol	2004