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p-SLP-76:ADAP binds Ena/VASP
Stable Identifier
R-HSA-430201
Type
Reaction [binding]
Species
Homo sapiens
Compartment
cytosol
ReviewStatus
5/5
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Immune System (Homo sapiens)
Adaptive Immune System (Homo sapiens)
TCR signaling (Homo sapiens)
Generation of second messenger molecules (Homo sapiens)
p-SLP-76:ADAP binds Ena/VASP (Homo sapiens)
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ADAP (FYB) is an adaptor protein containing multiple binding motifs including an enabled protein vasodilator-stimulated phosphoprotein homology domain 1 (EVH1)-binding domain. This domain binds Ena-VASP family proteins that regulate actin dynamics. The Ena-VASP family member EVL is found in regions of dynamic actin polymerization, such as F-actin rich patches and the distal tips of microspikes.
Literature References
PubMed ID
Title
Journal
Year
10747096
Fyn-binding protein (Fyb)/SLP-76-associated protein (SLAP), Ena/vasodilator-stimulated phosphoprotein (VASP) proteins and the Arp2/3 complex link T cell receptor (TCR) signaling to the actin cytoskeleton
Konradt, M
,
Krause, M
,
Wehland, J
,
Gertler, FB
,
Sechi, AS
,
Monner, D
J Cell Biol
2000
Participants
Input
Ena/VASP proteins [cytosol]
(Homo sapiens)
p-SLP-76:ADAP [cytosol]
(Homo sapiens)
Output
p-SLP-76:ADAP:Ena/VASP [cytosol]
(Homo sapiens)
Participates
as an event of
Generation of second messenger molecules (Homo sapiens)
Inferred From
p-SLP-76:ADAP binds Ena/VASP (Mus musculus)
Authored
Akkerman, JW (2009-06-03)
Reviewed
Harper, MT (2009-11-02)
Poole, AW (2009-11-02)
Jones, ML (2009-11-02)
Created
Jupe, S (2009-08-04)
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