Reactome | p-SLP-76 binds ADAP

p-SLP-76 binds ADAP

Stable Identifier

R-HSA-430135

Type

Reaction [binding]

Species

Homo sapiens

Compartment

cytosol

ReviewStatus

5/5

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SLP-76 inducibly-associates with ADAP (also known as FYN-binding protein or SLAP-130) a hematopoietic-specific adapter protein. ADAP has been implicated in T cell migration and rearrangement of the actin cytoskeleton. In platelets, adhesion to fibrinogen stimulates the association of SLP-76 with ADAP and VASP (Obergfell et al. 2001). ADAP knockout mice exhibit mild thrombocytopenia (Kasirer-Friede et al. 2007).

Literature References

PubMed ID	Title	Journal	Year
9115214	Molecular cloning of SLAP-130, an SLP-76-associated substrate of the T cell antigen receptor-stimulated protein tyrosine kinases Musci, MA, Hendricks-Taylor, LR, Motto, DG, Paskind, M, Kamens, J, Turck, CW, Koretzky, GA	J Biol Chem	1997
10671560	Functional association between SLAP-130 and SLP-76 in Jurkat T cells Boerth, NJ, Judd, BA, Koretzky, GA	J Biol Chem	2000