p-SLP-76 binds ADAP

Stable Identifier
R-HSA-430135
Type
Reaction [binding]
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
General
SVG |   | PPTX  | SBGN
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

SLP-76 inducibly-associates with ADAP (also known as FYN-binding protein or SLAP-130) a hematopoietic-specific adapter protein. ADAP has been implicated in T cell migration and rearrangement of the actin cytoskeleton. In platelets, adhesion to fibrinogen stimulates the association of SLP-76 with ADAP and VASP (Obergfell et al. 2001). ADAP knockout mice exhibit mild thrombocytopenia (Kasirer-Friede et al. 2007).

Literature References
PubMed ID Title Journal Year
10671560 Functional association between SLAP-130 and SLP-76 in Jurkat T cells

Boerth, NJ, Judd, BA, Koretzky, GA

J Biol Chem 2000
9115214 Molecular cloning of SLAP-130, an SLP-76-associated substrate of the T cell antigen receptor-stimulated protein tyrosine kinases

Musci, MA, Hendricks-Taylor, LR, Motto, DG, Paskind, M, Kamens, J, Turck, CW, Koretzky, GA

J Biol Chem 1997
Participants
Participant Of
Orthologous Events
Authored
Reviewed
Created