Reactome | GP1b-IX-V binds 14-3-3-zeta

GP1b-IX-V binds 14-3-3-zeta

Stable Identifier

R-HSA-430076

Type

Reaction [binding]

Species

Homo sapiens

Compartment

cytosol, plasma membrane

ReviewStatus

5/5

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The Gp1b-IX-V complex binds to 14-3-3-zeta, a scaffolding protein. The highly conserved cytoplasmic domain of GpIb alpha binds directly to dimeric 14-3-3 zeta adapter protein. Binding also involves regions of GpV, and is enhanced by phosphorylation of GP1b at Ser-609 or Ser-166 of Gp1b alpha and beta respectively. For Gp1b beta this phosphorylation is PKA-dependent.

Literature References

PubMed ID	Title	Journal	Year
8034572	Association of a phospholipase A2 (14-3-3 protein) with the platelet glycoprotein Ib-IX complex Du, X, Berndt, MC, Ginsberg, MH, Harris, SJ, Tetaz, TJ	J Biol Chem	1994
8631758	Identification of a binding sequence for the 14-3-3 protein within the cytoplasmic domain of the adhesion receptor, platelet glycoprotein Ib alpha Du, X, Fox, JE, Pei, S	J Biol Chem	1996
10627461	Cytoplasmic domains of GpIbalpha and GpIbbeta regulate 14-3-3zeta binding to GpIb/IX/V Christodoulides, N, Reséndiz, JC, Kroll, MH, Berndt, MC, Feng, S	Blood	2000
9425086	Binding of purified 14-3-3 zeta signaling protein to discrete amino acid sequences within the cytoplasmic domain of the platelet membrane glycoprotein Ib-IX-V complex Berndt, MC, Andrews, RK, Harris, SJ, McNally, T	Biochemistry	1998