GPIb-IX-V binding to 14-3-3 zeta is reduced by shear stress

Stable Identifier
R-HSA-430073
Type
Reaction [dissociation]
Species
Homo sapiens
Compartment
cytosol, plasma membrane
ReviewStatus
5/5
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GPIb-IX-V binding to 14-3-3 zeta is reduced by shear stress
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High shear stress, or immobilization of VWF under high shear conditions induce VWF binding to GPIb-IX-V. This activation mechanism is believed to involve shear-stress induced conformational changes in vWF.
Literature References
PubMed ID Title Journal Year
2010539 The role of von Willebrand factor and fibrinogen in platelet aggregation under varying shear stress

Araki, Y, Kawano, K, Handa, M, Anbo, H, Ikeda, Y, Kamata, T, Itagaki, I, Murata, M, Watanabe, K, Kawai, Y

J Clin Invest 1991
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Orthologous Events
GPIb-IX-V binding to 14-3-3 zeta is reduced by shear stress (Bos taurus)
GPIb-IX-V binding to 14-3-3 zeta is reduced by shear stress (Danio rerio)
GPIb-IX-V binding to 14-3-3 zeta is reduced by shear stress (Gallus gallus)
GPIb-IX-V binding to 14-3-3 zeta is reduced by shear stress (Mus musculus)
GPIb-IX-V binding to 14-3-3 zeta is reduced by shear stress (Rattus norvegicus)
GPIb-IX-V binding to 14-3-3 zeta is reduced by shear stress (Sus scrofa)
GPIb-IX-V binding to 14-3-3 zeta is reduced by shear stress (Xenopus tropicalis)
Authored
Akkerman, JW  (2009-06-03)
Reviewed
Kunapuli, SP  (2010-06-07)
Created
Jupe, S  (2009-07-30)
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