Reactome | CNOT8 [cytosol]

CNOT8 [cytosol]

Stable Identifier

R-HSA-429979

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

CCR4-NOT transcription complex subunit 8, CNOT8_HUMAN

Locations in the PathwayBrowser

Expand all

Gene expression (Transcription) (Homo sapiens)

- RNA Polymerase II Transcription (Homo sapiens)
  - Generic Transcription Pathway (Homo sapiens)
    - Transcriptional Regulation by TP53 (Homo sapiens)
      - TP53 Regulates Transcription of Cell Cycle Genes (Homo sapiens)
        
        TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain (Homo sapiens)
        
        BTG2 binds CCR4-NOT complex (Homo sapiens)
        
        BTG2:CCR4-NOT [cytosol] (Homo sapiens)
        
        CCR4-NOT Complex [cytosol] (Homo sapiens)
        
        CNOT7 or CNOT8 [cytosol] (Homo sapiens)
        
        CNOT8 [cytosol] (Homo sapiens)
        
        CCR4-NOT Complex [cytosol] (Homo sapiens)
        
        CNOT7 or CNOT8 [cytosol] (Homo sapiens)
        
        CNOT8 [cytosol] (Homo sapiens)

External Reference Information

External Reference

UniProt:Q9UFF9 CNOT8

Gene Names

CNOT8, CALIF, POP2

Chain

chain:1-292

Reference Genes

BioGPS Gene:9337 CNOT8

COSMIC (genes):CNOT8 CNOT8

CTD Gene:9337 CNOT8

dbSNP Gene:9337 CNOT8

ENSEMBL:ENSG00000155508 CNOT8

HGNC:9207 CNOT8

KEGG:hsa:9337 CNOT8

Monarch:9337 CNOT8

NCBI Entrez Gene:9337 CNOT8

OMIM:603731 CNOT8

UCSC:Q9UFF9 CNOT8

Reference Transcript

Other Identifiers

11742949_a_at

11742950_s_at

11746336_a_at

11749819_x_at

16991420

202162_PM_s_at

202162_s_at

202163_PM_s_at

202163_s_at

202164_PM_s_at

202164_s_at

2836857

2836858

2836859

2836860

2836861

2836862

2836863

2836864

2836865

2836866

2836867

2836868

2836869

2836870

2836871

2836872

2836873

2836874

2836876

2836877

2836879

2836880

41360_at

8109462

9337

A_14_P121203

A_23_P110846

GE54490

GO:0000175

GO:0000288

GO:0000289

GO:0000932

GO:0003676

GO:0003723

GO:0003824

GO:0004518

GO:0004527

GO:0004535

GO:0005515

GO:0005634

GO:0005737

GO:0005829

GO:0006417

GO:0008284

GO:0016787

GO:0030014

GO:0030015

GO:0031047

GO:0035279

GO:0043226

GO:0046872

GO:0061014

GO:0140098

HMNXSV003000389

Hs.26703.0.A1_3p_a_at

ILMN_1736068

ILMN_2174612

PH_hs_0002358

TC05000856.hg

g6856208_3p_a_at

Participates

as a member of

CNOT7 or CNOT8 [cytosol] (Homo sapiens)

Inferred To

cnot8 [cytosol] (Danio rerio)

cnot8 [cytosol] (Xenopus tropicalis)

Cnot8 [cytosol] (Mus musculus)

Homologues of CNOT8 [cytosol] (Dictyostelium discoideum)

CNOT8 [cytosol] (Bos taurus)

CNOT8 [cytosol] (Canis familiaris)

CNOT8 [cytosol] (Dictyostelium discoideum)

CNOT8 [cytosol] (Gallus gallus)

CNOT8 [cytosol] (Rattus norvegicus)

CNOT8 [cytosol] (Sus scrofa)

Cross References

RefSeq

XP_054209789.1, XP_047273847.1, XP_054209792.1, XP_047273836.1, XP_047273841.1, XP_016865545.1, NP_001288012.1, NP_004770.4, XP_054209787.1, XP_047273843.1, XP_054209780.1, XP_047273839.1, XP_016865541.1, NP_001288003.1, XP_016865537.1, XP_054209778.1, XP_047273837.1, XP_054209793.1, XP_016865544.1, XP_054209788.1, XP_016865542.1, XP_054209784.1, XP_054209790.1, XP_016865538.1, XP_047273840.1, XP_054209779.1, XP_047273844.1, XP_047273838.1, NP_001288015.1, NP_001288002.1, NP_001288006.1, XP_054209791.1, XP_047273845.1, XP_054209785.1, NP_001288009.1, XP_016865543.1, XP_054209781.1, XP_054209783.1, XP_016865539.1, XP_054209786.1, XP_005268584.1, XP_047273846.1, XP_011536008.1, XP_054209782.1, NP_001288011.1, XP_011536010.1, XP_016865546.1, XP_047273842.1, XP_054209794.1, XP_016865540.1, NP_001288004.1

OpenTargets

ENSG00000155508

ENSEMBL

ENSP00000384747, ENST00000285896, ENST00000403027, ENSP00000430493, ENSP00000428565, ENSP00000428305, ENSP00000430833, ENSP00000285896, ENSP00000431034, ENST00000521583, ENST00000523698, ENST00000517876, ENST00000520671, ENST00000521450, ENSP00000429882, ENST00000519404, ENSG00000155508

HPA

ENSG00000155508-CNOT8

GeneCards

CNOT8

PRO

Q9UFF9

Pharos - Targets

Q9UFF9

GlyGen

Q9UFF9

Interactors (5)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P62324 BTG1	1	BTG1 [nucleoplasm] (R-HSA-9620886)	0.835	6
UniProt:P78543 BTG2	1	BTG2 [cytosol] (R-HSA-6798008)	0.703	5
UniProt:P47756 CAPZB	1	CAPZB [cytosol] (R-HSA-879409)	0.643	3
UniProt:P52907 CAPZA1	2	CAPZA1(265-276) [extracellular region] (R-HSA-879421) CAPZA1 [cytosol] (R-HSA-879363)	0.564	2
UniProt:P09237 MMP7	6	MMP7(95-267) [extracellular region] (R-HSA-1442479) MMP7(18-267) [extracellular region] (R-HSA-1604734) MMP7(18-94) [extracellular region] (R-HSA-1604729) MMP7(51-267) [extracellular region] (R-HSA-1604766) MMP7(18-50) [extracellular region] (R-HSA-1604759) MMP7(51-94) [extracellular region] (R-HSA-1604760)	0.527	2

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