Reactome | DCPS scavenges the 7-methylguanosine cap of mRNA

DCPS scavenges the 7-methylguanosine cap of mRNA

Stable Identifier

R-HSA-429961

Type

Reaction [transition]

Species

Homo sapiens

Compartment

cytosol

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DCPS scavenges the 7-methylguanosine cap of mRNA

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The scavenging nuclease DCPS hydrolyzes the triphosphate bond between the 7-methylguanosine cap and the remaining oligoribonucleotide body of the mRNA. The products are 7-methylguanosine 5'-monophosphate and an oligoribonucleotide with a 5'-diphosphate.

Literature References

PubMed ID	Title	Journal	Year
16141059	From birth to death: the complex lives of eukaryotic mRNAs Moore, MJ	Science	2005
14749774	The enzymes and control of eukaryotic mRNA turnover Parker, R, Song, H	Nat Struct Mol Biol	2004
18441014	Mechanistic and kinetic analysis of the DcpS scavenger decapping enzyme Liu, SW, Rajagopal, V, Patel, SS, Kiledjian, M	J Biol Chem	2008
15475613	Messenger RNA decay in mammalian cells: the exonuclease perspective Fritz, DT, Bergman, N, Kilpatrick, WJ, Wilusz, CJ, Wilusz, J	Cell Biochem Biophys	2004
15769464	Crystal structures of human DcpS in ligand-free and m7GDP-bound forms suggest a dynamic mechanism for scavenger mRNA decapping Chen, N, Walsh, MA, Liu, Y, Parker, R, Song, H	J Mol Biol	2005
15273322	Functional analysis of mRNA scavenger decapping enzymes Liu, SW, Jiao, X, Liu, H, Gu, M, Lima, CD, Kiledjian, M	RNA	2004
19239894	The many pathways of RNA degradation Houseley, J, Tollervey, D	Cell	2009
17245413	The highways and byways of mRNA decay Garneau, NL, Wilusz, J, Wilusz, CJ	Nat Rev Mol Cell Biol	2007
15068804	Insights into the structure, mechanism, and regulation of scavenger mRNA decapping activity Gu, M, Fabrega, C, Liu, SW, Liu, H, Kiledjian, M, Lima, CD	Mol Cell	2004
11283721	The cap-to-tail guide to mRNA turnover Wilusz, CJ, Wormington, M, Peltz, SW	Nat Rev Mol Cell Biol	2001