Reactome | CNOT3 [cytosol]

CNOT3 [cytosol]

Stable Identifier

R-HSA-429872

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

CCR4-NOT transcription complex subunit 3, CNOT3_HUMAN

Locations in the PathwayBrowser

Expand all

Gene expression (Transcription) (Homo sapiens)

- RNA Polymerase II Transcription (Homo sapiens)
  - Generic Transcription Pathway (Homo sapiens)
    - Transcriptional Regulation by TP53 (Homo sapiens)
      - TP53 Regulates Transcription of Cell Cycle Genes (Homo sapiens)
        
        TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain (Homo sapiens)
        
        BTG2 binds CCR4-NOT complex (Homo sapiens)
        
        BTG2:CCR4-NOT [cytosol] (Homo sapiens)
        
        CCR4-NOT Complex [cytosol] (Homo sapiens)
        
        CNOT3 [cytosol] (Homo sapiens)
        
        CCR4-NOT Complex [cytosol] (Homo sapiens)
        
        CNOT3 [cytosol] (Homo sapiens)

External Reference Information

External Reference

UniProt:O75175 CNOT3

Gene Names

CNOT3, KIAA0691, LENG2, NOT3

Chain

chain:1-753

Reference Genes

BioGPS Gene:4849 CNOT3

COSMIC (genes):CNOT3 CNOT3

CTD Gene:4849 CNOT3

dbSNP Gene:4849 CNOT3

ENSEMBL:ENSG00000088038 CNOT3

ENSEMBL:ENSG00000088038.20 CNOT3

ENSEMBL:ENSG00000273943.4 CNOT3

ENSEMBL:ENSG00000274176.4 CNOT3

ENSEMBL:ENSG00000274616.4 CNOT3

ENSEMBL:ENSG00000274941.4 CNOT3

ENSEMBL:ENSG00000275979.4 CNOT3

ENSEMBL:ENSG00000276082.4 CNOT3

ENSEMBL:ENSG00000277114.4 CNOT3

ENSEMBL:ENSG00000277600.4 CNOT3

ENSEMBL:ENSG00000277615.4 CNOT3

HGNC:7879 CNOT3

KEGG Gene (Homo sapiens):4849 CNOT3

Monarch:4849 CNOT3

NCBI Gene:4849 CNOT3

OMIM:604910 CNOT3

UCSC:O75175 CNOT3

Reference Transcript

RefSeq:NM_014516.3 CNOT3

Other Identifiers

11722624_a_at

11748662_a_at

11748663_x_at

16865214

203239_3p_s_at

203239_PM_s_at

203239_s_at

211141_PM_s_at

211141_s_at

38310_at

3841261

3841264

3841265

3841266

3841267

3841268

3841270

3841271

3841273

3841274

3841276

3841278

3841279

3841281

3841282

3841283

3841284

3841285

3841286

3841287

3841288

3841292

3841297

3841298

3841299

3841300

3841301

4849

8031122

A_14_P100437

A_14_P121762

A_23_P38987

A_33_P3287685

GE53393

GO:0000289

GO:0000932

GO:0001829

GO:0005515

GO:0005634

GO:0005737

GO:0005829

GO:0006351

GO:0006355

GO:0006417

GO:0016071

GO:0030014

GO:0030015

GO:0030154

GO:0031047

GO:0043226

GO:0048856

GO:0120162

GO:2000036

HMNXSV003045653

ILMN_2207393

PH_hs_0016636

TC19000873.hg

g6856204_3p_a_at

g6856204_3p_x_at

g7657386_3p_a_at

g7657386_3p_at

g7657386_3p_x_at

Participates

as a component of

CCR4-NOT Complex [cytosol] (Homo sapiens)

Inferred To

Ghost homologue of CNOT3 [cytosol] (Gallus gallus)

Cnot3 [cytosol] (Mus musculus)

Cnot3 [cytosol] (Rattus norvegicus)

CNOT3 [cytosol] (Bos taurus)

CNOT3 [cytosol] (Canis familiaris)

CNOT3 [cytosol] (Dictyostelium discoideum)

CNOT3 [cytosol] (Sus scrofa)

cnot3 [cytosol] (Danio rerio)

cnot3 [cytosol] (Xenopus tropicalis)

Cross References

RefSeq

NP_055331.1

OpenTargets

ENSG00000088038

GeneCards

O75175

HPA

ENSG00000088038-CNOT3

Ensembl

ENST00000611252, ENSG00000277600, ENSG00000274616, ENSP00000483604, ENST00000618405, ENSP00000483968, ENST00000614649, ENST00000619567, ENST00000613752, ENST00000622131, ENSP00000483431, ENSP00000351159, ENST00000620573, ENSG00000088038, ENST00000620970, ENST00000620419, ENSP00000480988, ENSP00000481681, ENSG00000276082, ENSP00000481924, ENSP00000480876, ENSP00000221232, ENST00000221232, ENSP00000478956, ENSG00000277615, ENST00000616910, ENSG00000274176, ENSG00000274941, ENST00000617982, ENSP00000478280, ENST00000358389, ENSP00000480697, ENSP00000483882, ENSP00000479987, ENSP00000483036, ENST00000610883, ENST00000615030, ENSG00000277114, ENSP00000484040, ENSG00000275979, ENST00000620060, ENSG00000273943, ENSP00000484794, ENST00000612924, ENSP00000480258, ENSP00000480585, ENST00000619854, ENSP00000483692, ENST00000616359, ENST00000613528

PRO

O75175

Pharos - Targets

O75175

Orphanet

22045

PDB

5FU7, 4C0G, 5FU6, 4C0D

Interactors (3)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P55072 VCP	8	Me3K315-VCP [cytosol] (R-HSA-8932209) VCP [endoplasmic reticulum membrane] (R-HSA-8943105) VCP [nucleoplasm] (R-HSA-5643745) VCP [azurophil granule lumen] (R-HSA-6800438) VCP [secretory granule lumen] (R-HSA-6801039) VCP [extracellular region] (R-HSA-6806191) VCP [ficolin-1-rich granule lumen] (R-HSA-6800425) VCP [cytosol] (R-HSA-1181251)	0.556	3
UniProt:P16284 PECAM1	4	PECAM1 [plasma membrane] (R-HSA-114686) p-Y663,Y686-PECAM1(27-?) [plasma membrane] (R-HSA-210007) PECAM1 [secretory granule membrane] (R-HSA-6804778) PECAM1 [platelet alpha granule membrane] (R-HSA-61489)	0.556	3
UniProt:P27797 CALR	6	CALR [integral component of lumenal side of endoplasmic reticulum membrane] (R-HSA-985502) CALR [endoplasmic reticulum lumen] (R-HSA-195905) CALR [endoplasmic reticulum-Golgi intermediate compartment membrane] (R-HSA-8863866) CALR [phagocytic vesicle membrane] (R-HSA-1236879) CALR [extracellular region] (R-HSA-2197641) CALR [endocytic vesicle lumen] (R-HSA-2239448)	0.556	3

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