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XRN1 [cytosol]
Stable Identifier
R-HSA-429835
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
cytosol
Synonyms
5'-3' exoribonuclease 1, XRN1_HUMAN
Icon
Locations in the PathwayBrowser
Expand all
Metabolism of RNA (Homo sapiens)
Deadenylation-dependent mRNA decay (Homo sapiens)
mRNA decay by 5' to 3' exoribonuclease (Homo sapiens)
5' to 3' exoribonuclease hydrolyzes decapped mRNA (Homo sapiens)
XRN1 [cytosol] (Homo sapiens)
Regulation of mRNA stability by proteins that bind AU-rich elements (Homo sapiens)
Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA (Homo sapiens)
BRF1 Complex recruits RNA degradation activities (Homo sapiens)
BRF1:mRNA Degradation Complex [cytosol] (Homo sapiens)
XRN1 [cytosol] (Homo sapiens)
XRN1 [cytosol] (Homo sapiens)
Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA (Homo sapiens)
ZFP36 (TTP) recruits RNA degradation activities (Homo sapiens)
TTP:mRNA Degradation Complex [cytosol] (Homo sapiens)
XRN1 [cytosol] (Homo sapiens)
XRN1 [cytosol] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q8IZH2 XRN1
Gene Names
XRN1, SEP1
Chain
chain:1-1706
Reference Genes
BioGPS Gene:54464 XRN1
COSMIC (genes):XRN1 XRN1
CTD Gene:54464 XRN1
dbSNP Gene:54464 XRN1
ENSEMBL:ENSG00000114127 XRN1
HGNC:30654 XRN1
KEGG:hsa:54464 XRN1
Monarch:54464 XRN1
NCBI Gene:54464 XRN1
OMIM:607994 XRN1
UCSC:Q8IZH2 XRN1
Reference Transcript
RefSeq:NM_001282857.1 XRN1
RefSeq:NM_019001.4 XRN1
RefSeq:NM_001282859.1 XRN1
Other Identifiers
11740429_s_at
11743781_a_at
11749334_a_at
11760043_at
1555785_PM_a_at
1555785_a_at
1570394_PM_at
1570394_at
16959925
225814_PM_at
225814_at
233632_PM_s_at
233632_s_at
2698739
2698740
2698741
2698742
2698743
2698744
2698745
2698746
2698747
2698749
2698750
2698751
2698752
2698753
2698754
2698755
2698757
2698758
2698762
2698764
2698769
2698770
2698773
2698774
2698775
2698776
2698777
2698778
2698779
2698780
2698781
2698782
2698783
2698784
2698786
2698787
2698788
2698790
2698792
2698794
2698795
2698796
2698802
2698803
2698804
2698806
2698807
2698808
2698809
2698810
2698812
2698813
2698814
2698815
2698816
2698817
2698818
2698819
2698820
2698821
2698822
2698824
2698828
2698829
42920_at
46550_at
47090_at
54464
64909_at
8091141
86814_at
A_23_P132822
A_23_P319792
A_24_P393353
GE56638
GE682056
GO:0000932
GO:0000956
GO:0002151
GO:0003676
GO:0003677
GO:0003723
GO:0003824
GO:0004527
GO:0004534
GO:0005515
GO:0005634
GO:0005737
GO:0005829
GO:0005886
GO:0008409
GO:0016020
GO:0016071
GO:0016075
GO:0016787
GO:0017148
GO:0030425
GO:0032211
GO:0033574
GO:0043025
GO:0043226
GO:0051880
GO:0070034
GO:0071028
GO:0071044
GO:0071409
GO:0140098
GO:1905795
HMNXSV003006922
Hs.82501.0.S1_3p_at
Hs.82501.0.S1_3p_x_at
Hs.82501.1.S1_3p_a_at
Hs2.82501.1.S1_3p_s_at
Hs2.82501.4.S1_3p_at
ILMN_1809086
ILMN_2384216
PH_hs_0022460
TC03001851.hg
Participates
as a component of
TTP:mRNA Degradation Complex [cytosol] (Homo sapiens)
BRF1:mRNA Degradation Complex [cytosol] (Homo sapiens)
as an input of
ZFP36 (TTP) recruits RNA degradation activities (Homo sapiens)
BRF1 Complex recruits RNA degradation activities (Homo sapiens)
Inferred To
xrn1 [cytosol]
(Xenopus tropicalis)
dhp1 [cytosol]
(Schizosaccharomyces pombe)
xrn-1 [cytosol]
(Caenorhabditis elegans)
Xrn1 [cytosol]
(Mus musculus)
Xrn1 [cytosol]
(Rattus norvegicus)
xrn2 [cytosol]
(Dictyostelium discoideum)
RAT1 [cytosol]
(Saccharomyces cerevisiae)
XRN1 [cytosol]
(Bos taurus)
XRN1 [cytosol]
(Canis familiaris)
XRN1 [cytosol]
(Gallus gallus)
XRN1 [cytosol]
(Sus scrofa)
Cross References
RefSeq
NP_001269786.1
,
NP_061874.3
,
NP_001269788.1
ENSEMBL
ENSP00000264951
,
ENST00000392981
,
ENST00000264951
,
ENST00000463916
,
ENSP00000376707
,
ENSP00000418404
OpenTargets
ENSG00000114127
HPA
ENSG00000114127-XRN1
PRO
Q8IZH2
Pharos - Targets
Q8IZH2
GlyGen
Q8IZH2
Interactors (5)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q6P2E9 EDC4
1
EDC4 [cytosol]
(R-HSA-429963)
0.748
5
UniProt:P62249 RPS16
2
RPS16 [cytosol]
(R-HSA-72337)
RPS16 [nucleoplasm]
(R-HSA-6791196)
0.527
2
UniProt:Q92900-2 UPF1
0.527
2
UniProt:P09651 HNRNPA1
2
HNRNPA1 [nucleoplasm]
(R-HSA-71927)
HNRNPA1 [cytosol]
(R-HSA-9727902)
0.519
2
UniProt:Q86TB9 PATL1
1
PATL1 [cytosol]
(R-HSA-2028617)
0.462
4
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