Reactome | TXNDC5 [lysosomal lumen]

TXNDC5 [lysosomal lumen]

Stable Identifier

R-HSA-429813

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

lysosomal lumen

Synonyms

Thioredoxin domain-containing protein 5, TXND5_HUMAN

Locations in the PathwayBrowser

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External Reference Information

External Reference

UniProt:Q8NBS9 TXNDC5

Gene Names

TXNDC5, TLP46, UNQ364/PRO700

Chain

signal peptide:1-32, chain:33-432

Reference Genes

BioGPS Gene:81567 TXNDC5

COSMIC (genes):TXNDC5 TXNDC5

CTD Gene:81567 TXNDC5

dbSNP Gene:81567 TXNDC5

ENSEMBL:ENSG00000239264 TXNDC5

ENSEMBL_homo_sapiens_GENE:ENSG00000239264.9 TXNDC5

HGNC:21073 TXNDC5

KEGG Gene (Homo sapiens):81567 TXNDC5

Monarch:81567 TXNDC5

NCBI Gene:81567 TXNDC5

OMIM:616412 TXNDC5

UCSC:Q8NBS9 TXNDC5

Reference Transcript

Other Identifiers

11715395_a_at

11715396_s_at

221253_PM_s_at

221253_s_at

241141_PM_at

241141_at

2940824

2940825

2940827

2940828

2940829

2940830

2940831

2940832

2940833

2940838

2940839

2940841

2940844

2940848

2940851

2940855

2940856

2940864

2940865

2940866

2940867

46209_at

81567

A_23_P168229

A_33_P3270451

GE83181

GO:0003756

GO:0003824

GO:0005515

GO:0005576

GO:0005615

GO:0005764

GO:0005773

GO:0005783

GO:0005788

GO:0006457

GO:0012501

GO:0015035

GO:0016491

GO:0016853

GO:0031410

GO:0035578

GO:0043066

GO:0043202

GO:0043226

GO:0070062

GO:0140096

HMNXSV003045373

Hs.240058.0.A1_3p_at

ILMN_1769082

ILMN_1788108

PH_hs_0035950

TC06003448.hg

TC06004109.hg

g13540603_3p_s_at

p33708

Participates

as a component of

BLOC-1 Complex [lysosomal membrane] (Homo sapiens)

as an input of

Formation Of Bloc-1 Complex (Homo sapiens)

as a candidate of

Lysosome Cargo [lysosomal lumen] (Homo sapiens)

Other forms of this molecule

TXNDC5 [Golgi lumen]

TXNDC5 [extracellular region]

TXNDC5 [azurophil granule lumen]

Inferred To

txndc5 [lysosomal lumen] (Xenopus tropicalis)

Txndc5 [lysosomal lumen] (Mus musculus)

Txndc5 [lysosomal lumen] (Rattus norvegicus)

Homologues of TXNDC5 [lysosomal lumen] (Dictyostelium discoideum)

TXNDC5 [lysosomal lumen] (Bos taurus)

TXNDC5 [lysosomal lumen] (Canis familiaris)

TXNDC5 [lysosomal lumen] (Dictyostelium discoideum)

TXNDC5 [lysosomal lumen] (Gallus gallus)

TXNDC5 [lysosomal lumen] (Sus scrofa)

prtp [lysosomal lumen] (Drosophila melanogaster)

Cross References

RefSeq

NP_110437.2, NP_001139021.1

OpenTargets

ENSG00000239264

IntEnz

5.3.4.1

GeneCards

Q8NBS9

HPA

ENSG00000239264-TXNDC5

Ensembl

ENST00000379757, ENSG00000239264, ENSP00000369081, ENST00000473453, ENSP00000420784

PRO

Q8NBS9

Pharos - Targets

Q8NBS9

PDB

3WGD, 3WGX, 2DIZ, 3WGE, 3UJ1, 3UVT, 8EKY

Interactors (5)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q9UHD9 UBQLN2	1	UBQLN2 [cytosol] (R-HSA-8866007)	0.556	3
UniProt:P0DTC3 3a	9	O-glycosyl 3a [virion membrane] (R-COV-9694395) O-glycosyl 3a [endocytic vesicle membrane] (R-COV-9694729) O-glycosyl 3a [endoplasmic reticulum-Golgi intermediate compartment membrane] (R-COV-9694386) GalNAc-O-3a [endoplasmic reticulum-Golgi intermediate compartment] (R-COV-9694658) 3a [endoplasmic reticulum-Golgi intermediate compartment] (R-COV-9694716) 3a [endoplasmic reticulum lumen] (R-COV-9694584) O-glycosyl 3a [endolysosome membrane] (R-COV-9754541) O-glycosyl 3a [plasma membrane] (R-COV-9694433) O-glycosyl 3a [extracellular region] (R-COV-9694387)	0.547	2
UniProt:P61962 DCAF7	2	DCAF7 [nucleoplasm] (R-HSA-8863312) Unfolded DCAF7 [cytosol] (R-HSA-6813821)	0.508	2
UniProt:Q99IB8-PRO_0000045602			0.462	5
UniProt:Q2HXL6 EDEM3			0.462	2

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