Passive I- efflux mediated by SMCT1

Stable Identifier
R-HSA-429767
Type
Reaction [transition]
Species
Homo sapiens
Compartment
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SLC5A8 encodes for the apical iodide transporter, AIT (also known as SMCT1). As well as functioning as a Na+-dependent monocarboxylate co-transporter, AIT also mediates iodide transport from the thyrocyte into the colloid lumen through the apical membrane (Rodriguez AM et al, 2002). AIT, together with NIS (see previous reaction), mediates iodide transfer from blood to the colloid lumen of thyrocytes.

Literature References
PubMed ID Title Journal Year
12107270 Identification and characterization of a putative human iodide transporter located at the apical membrane of thyrocytes

Rodriguez, AM, Perron, B, Lacroix, L, Caillou, B, Leblanc, G, Schlumberger, M, Bidart, JM, Pourcher, T

J Clin Endocrinol Metab 2002
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
passive transmembrane transporter activity of SLC5A8 [plasma membrane]
Physical Entity
Activity
Orthologous Events
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Created
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