Reactome | Multiphospho-CERT1-2 binds PPM1L, VAPA/B

Multiphospho-CERT1-2 binds PPM1L, VAPA/B

Stable Identifier

R-HSA-429732

Type

Reaction [binding]

Species

Homo sapiens

Compartment

cytosol, endoplasmic reticulum membrane

Synonyms

multiphospho-CERT + PPM1L:VAPA/B => multiphospho-CERT:PPM1L:VAPA/B

ReviewStatus

5/5

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Multiphospho-CERT1-2 binds PPM1L, VAPA/B

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Multiphospho-CERT retains its affinity for VAPA or VAPB (VAMP-associated proteins A or B) and PPM1L (protein phosphatase 1-like) in the endoplasmic reticulum membrane, and can associate with them to form a membrane-associated complex (Kawano et al., 2006; Saito et al. 2008; reviewed by Kumagai & Hanada, 2019).

Literature References

PubMed ID	Title	Journal	Year
18165232	Protein phosphatase 2Cepsilon is an endoplasmic reticulum integral membrane protein that dephosphorylates the ceramide transport protein CERT to enhance its association with organelle membranes Tamura, S, Saito, S, Kobayashi, T, Echigo, S, Kawano, M, Matsui, H, Hanada, K, Tomishige, N, Kumagai, K	J Biol Chem	2008
31254361	Structure, functions and regulation of CERT, a lipid-transfer protein for the delivery of ceramide at the ER-Golgi membrane contact sites Hanada, K, Kumagai, K	FEBS Lett	2019
16895911	Efficient trafficking of ceramide from the endoplasmic reticulum to the Golgi apparatus requires a VAMP-associated protein-interacting FFAT motif of CERT Kawano, M, Hanada, K, Kumagai, K, Nishijima, M	J Biol Chem	2006