CSNK1G2 phosphorylates p-CERT1-2

Stable Identifier
R-HSA-429714
Type
Reaction [transition]
Species
Homo sapiens
Compartment
Synonyms
monophospho-CERT + 2 ATP => multiphospho-CERT + 2 ADP
ReviewStatus
5/5
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Cytosolic CSNK1G2 (casein kinase 1, gamma 2) catalyzes the phosphorylation of multiple serine and threonine residues of “CERT” (ceramide transfer protein) already phosphorylated on serine-132 (Tomishige et al. 2009). This reaction has the effect of inhibiting ceramide transport from the endoplasmic reticulum to the Golgi apparatus as multiphospho-CERT is unable to bind ceramides or associate with the Golgi membrane (reviewed by Kumagai & Hanada, 2019).
Literature References
PubMed ID Title Journal Year
19005213 Casein kinase I{gamma}2 down-regulates trafficking of ceramide in the synthesis of sphingomyelin

Hanada, K, Kusuda, J, Kumagai, K, Tomishige, N, Nishijima, M

Mol Biol Cell 2009
31254361 Structure, functions and regulation of CERT, a lipid-transfer protein for the delivery of ceramide at the ER-Golgi membrane contact sites

Hanada, K, Kumagai, K

FEBS Lett 2019
Participants
Participates
Catalyst Activity

protein serine/threonine kinase activity of CSNK1G2 [cytosol]

Orthologous Events
Authored
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