CERT1-2 binds ceramide

Stable Identifier
R-HSA-429699
Type
Reaction [binding]
Species
Homo sapiens
Compartment
Synonyms
CERT protein binds ceramide associated with the endoplasmic reticulum membrane
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CERT1-2 (ceramide transfer protein, isoform 2), an isoform of COL4A3BP, mediates the translocation of ceramides from the endoplasmic reticulum (ER) membrane to the membrane of the Golgi apparatus. Immunoprecipitation experiments suggest that CERT1-2 is associated with the ER membrane as part of a complex with PPM1L (protein phosphatase 1-like) (Saito et al. 2008) and VAPA or VAPB (VAMP-associated proteins A or B) (Kawano et al. 2006). The carboxyterminal START domain of CERT1-2 protein specifically binds ceramides (Hanada et al. 2003; Kudo et al. 2008).

Literature References
PubMed ID Title Journal Year
18165232 Protein phosphatase 2Cepsilon is an endoplasmic reticulum integral membrane protein that dephosphorylates the ceramide transport protein CERT to enhance its association with organelle membranes

Tamura, S, Saito, S, Kobayashi, T, Echigo, S, Kawano, M, Matsui, H, Hanada, K, Tomishige, N, Kumagai, K

J Biol Chem 2008
18184806 Structural basis for specific lipid recognition by CERT responsible for nonvesicular trafficking of ceramide

Wakatsuki, S, Kato, R, Yamaji, T, Hanada, K, Tomishige, N, Kumagai, K, Nishijima, M, Kudo, N

Proc Natl Acad Sci U S A 2008
14685229 Molecular machinery for non-vesicular trafficking of ceramide

Yasuda, S, Miura, Y, Kawano, M, Fukasawa, M, Kumagai, K, Hanada, K, Nishijima, M

Nature 2003
16895911 Efficient trafficking of ceramide from the endoplasmic reticulum to the Golgi apparatus requires a VAMP-associated protein-interacting FFAT motif of CERT

Kawano, M, Hanada, K, Kumagai, K, Nishijima, M

J Biol Chem 2006
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