PRKD1,2,3 phosphorylates CERT1-2

Stable Identifier
R-HSA-429698
Type
Reaction [transition]
Species
Homo sapiens
Compartment
Synonyms
CERT + ATP => monophospho-CERT + ADP
ReviewStatus
5/5
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Cytosolic PRKD1, 2, and 3 (protein kinase D1, D2, and D3) catalyze the phosphorylation of serine residue 132 of isoform 2 of ceramide transfer protein (CERT1-2, aka COL4A3BP-2). Protein kinase D (PRKD) is a crucial regulator of secretory transport at the trans-Golgi network (TGN). Phosphorylation of COL4A3BP-2 reduces its ceramide transfer activity. PRKDs may, therefore, act as regulators of lipid homeostasis (Fugmann et al., 2007; Kumagai et al., 2014; Shimasaki et al., 2022; reviewed by Olayioye & Hausser, 2011; Kumagai & Hanada, 2019).

Participants
Participates
Catalyst Activity

protein kinase C activity of PRKD1,2,3 [cytosol]

Orthologous Events
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