CERT:ceramide [ER] => ceramide [Golgi] + CERT [ER]

Stable Identifier
Reaction [dissociation]
Homo sapiens
“CERT” protein releases its bound ceramide into the membrane of the Golgi apparatus
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“CERT” (ceramide transfer protein), associated with the cytosolic face of the endoplasmic reticulum (ER) in a complex with VAPA or VAPB (VAMP-associated proteins A or B) (Kawano et al. 2006) and PPM1L (protein phosphatase 1-like) (Saito et al. 2008), can bridge the gap between the ER and the Golgi apparatus via its PH domain and transfer a molecule of ceramide extracted from the ER membrane to the Golgi (Hanada et al. 2003; Saito et al. 2008). “CERT”-mediated ceramide transfer is positively regulated by OSBP (oxysterol binding protein), by an unknown mechanism (Perry and Ridgway 2006).

Literature References
PubMed ID Title Journal Year
18165232 Protein phosphatase 2Cepsilon is an endoplasmic reticulum integral membrane protein that dephosphorylates the ceramide transport protein CERT to enhance its association with organelle membranes

Saito, S, Matsui, H, Kawano, M, Kumagai, K, Tomishige, N, Hanada, K, Echigo, S, Tamura, S, Kobayashi, T

J Biol Chem 2008
16571669 Oxysterol-binding protein and vesicle-associated membrane protein-associated protein are required for sterol-dependent activation of the ceramide transport protein

Perry, RJ, Ridgway, ND

Mol Biol Cell 2006
14685229 Molecular machinery for non-vesicular trafficking of ceramide

Hanada, K, Kumagai, K, Yasuda, S, Miura, Y, Kawano, M, Fukasawa, M, Nishijima, M

Nature 2003
16895911 Efficient trafficking of ceramide from the endoplasmic reticulum to the Golgi apparatus requires a VAMP-associated protein-interacting FFAT motif of CERT

Kawano, M, Kumagai, K, Nishijima, M, Hanada, K

J Biol Chem 2006
This event is regulated
Positively by
Orthologous Events
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