CERT1-2 releases its bound ceramide into the membrane of the Golgi apparatus

Stable Identifier
R-HSA-429683
Type
Reaction [dissociation]
Species
Homo sapiens
Compartment
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CERT1-2 (ceramide transfer protein, isoform 2), associated with the cytosolic face of the endoplasmic reticulum (ER) in a complex with VAPA or VAPB (VAMP-associated proteins A or B) (Kawano et al. 2006) and PPM1L (protein phosphatase 1-like) (Saito et al. 2008), can bridge the gap between the ER and the Golgi apparatus via its PH domain and transfer a molecule of ceramide extracted from the ER membrane to the Golgi (Hanada et al. 2003; Saito et al. 2008). CERT1-2-mediated ceramide transfer is positively regulated by OSBP (oxysterol binding protein), by an unknown mechanism (Perry and Ridgway 2006).

Literature References
PubMed ID Title Journal Year
16571669 Oxysterol-binding protein and vesicle-associated membrane protein-associated protein are required for sterol-dependent activation of the ceramide transport protein

Ridgway, ND, Perry, RJ

Mol Biol Cell 2006
18165232 Protein phosphatase 2Cepsilon is an endoplasmic reticulum integral membrane protein that dephosphorylates the ceramide transport protein CERT to enhance its association with organelle membranes

Tamura, S, Saito, S, Kobayashi, T, Echigo, S, Kawano, M, Matsui, H, Hanada, K, Tomishige, N, Kumagai, K

J Biol Chem 2008
14685229 Molecular machinery for non-vesicular trafficking of ceramide

Yasuda, S, Miura, Y, Kawano, M, Fukasawa, M, Kumagai, K, Hanada, K, Nishijima, M

Nature 2003
16895911 Efficient trafficking of ceramide from the endoplasmic reticulum to the Golgi apparatus requires a VAMP-associated protein-interacting FFAT motif of CERT

Kawano, M, Hanada, K, Kumagai, K, Nishijima, M

J Biol Chem 2006
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