Reactome | CERT1-2 releases its bound ceramide into the membrane of the Golgi apparatus

CERT1-2 releases its bound ceramide into the membrane of the Golgi apparatus

Stable Identifier

R-HSA-429683

Type

Reaction [dissociation]

Species

Homo sapiens

Compartment

endoplasmic reticulum membrane

ReviewStatus

5/5

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CERT1-2 releases its bound ceramide into the membrane of the Golgi apparatus

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CERT1-2 (ceramide transfer protein, isoform 2), associated with the cytosolic face of the endoplasmic reticulum (ER) in a complex with VAPA or VAPB (VAMP-associated proteins A or B) (Kawano et al. 2006) and PPM1L (protein phosphatase 1-like) (Saito et al. 2008), can bridge the gap between the ER and the Golgi apparatus via its PH domain and transfer a molecule of ceramide extracted from the ER membrane to the Golgi (Hanada et al. 2003; Saito et al. 2008). CERT1-2-mediated ceramide transfer is positively regulated by OSBP (oxysterol binding protein), by an unknown mechanism (Perry and Ridgway 2006).

Literature References

PubMed ID	Title	Journal	Year
16571669	Oxysterol-binding protein and vesicle-associated membrane protein-associated protein are required for sterol-dependent activation of the ceramide transport protein Ridgway, ND, Perry, RJ	Mol Biol Cell	2006
18165232	Protein phosphatase 2Cepsilon is an endoplasmic reticulum integral membrane protein that dephosphorylates the ceramide transport protein CERT to enhance its association with organelle membranes Tamura, S, Saito, S, Kobayashi, T, Echigo, S, Kawano, M, Matsui, H, Hanada, K, Tomishige, N, Kumagai, K	J Biol Chem	2008
14685229	Molecular machinery for non-vesicular trafficking of ceramide Yasuda, S, Miura, Y, Kawano, M, Fukasawa, M, Kumagai, K, Hanada, K, Nishijima, M	Nature	2003
16895911	Efficient trafficking of ceramide from the endoplasmic reticulum to the Golgi apparatus requires a VAMP-associated protein-interacting FFAT motif of CERT Kawano, M, Hanada, K, Kumagai, K, Nishijima, M	J Biol Chem	2006