Reactome | SLC5A3 (SMIT1) transports myo-inositol (Ins) with Na+ from extracellular region to cytosol

SLC5A3 (SMIT1) transports myo-inositol (Ins) with Na+ from extracellular region to cytosol

Stable Identifier

R-HSA-429663

Type

Reaction [transition]

Species

Homo sapiens

Compartment

plasma membrane

Synonyms

Co-transport (influx) of myo-inositol and two Na+ ions by SMIT

ReviewStatus

5/5

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SLC5A3 (SMIT1) transports myo-inositol (Ins) with Na+ from extracellular region to cytosol

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The human SLC5A3 gene encodes a Na+/myo-inositol (Ins) transporter also known as SMIT1 (Berry et al. 1995). The stoichiometry and inositol specificity of the human transport reaction are inferred from the properties of cloned canine protein expressed in Xenopus oocytes (Hager et al. 1995). SMIT1 functions in cellular osmoregulation and is expressed in many human tissues including skeletal muscle, brain, kidney, and placenta.

Literature References

PubMed ID	Title	Journal	Year
7537337	Kinetics and specificity of the renal Na+/myo-inositol cotransporter expressed in Xenopus oocytes Hazama, A, Loo, DD, Kwon, HM, Wright, EM, Handler, JS, Hager, K	J. Membr. Biol.	1995
7789985	The human osmoregulatory Na+/myo-inositol cotransporter gene (SLC5A3): molecular cloning and localization to chromosome 21 Berry, GT, Mulla, WR, Spinner, NB, Mallee, JJ, Muenke, M, Rim, JS, Kwon, HM	Genomics	1995