SLC5A3 (SMIT1) transports myo-inositol (Ins) with Na+ from extracellular region to cytosol

Stable Identifier
R-HSA-429663
Type
Reaction [transition]
Species
Homo sapiens
Compartment
Synonyms
Co-transport (influx) of myo-inositol and two Na+ ions by SMIT
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The human SLC5A3 gene encodes a Na+/myo-inositol (Ins) transporter also known as SMIT1 (Berry et al. 1995). The stoichiometry and inositol specificity of the human transport reaction are inferred from the properties of cloned canine protein expressed in Xenopus oocytes (Hager et al. 1995). SMIT1 functions in cellular osmoregulation and is expressed in many human tissues including skeletal muscle, brain, kidney, and placenta.

Literature References
PubMed ID Title Journal Year
7789985 The human osmoregulatory Na+/myo-inositol cotransporter gene (SLC5A3): molecular cloning and localization to chromosome 21

Berry, GT, Mallee, JJ, Kwon, HM, Rim, JS, Mulla, WR, Muenke, M, Spinner, NB

Genomics 1995
7537337 Kinetics and specificity of the renal Na+/myo-inositol cotransporter expressed in Xenopus oocytes

Hager, K, Hazama, A, Kwon, HM, Loo, DD, Handler, JS, Wright, EM

J. Membr. Biol. 1995
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
myo-inositol:sodium symporter activity of SLC5A3 [plasma membrane]
Physical Entity
Activity
Orthologous Events
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