SLC5A7 cotransports Cho, Cl-, Na+ from extracellular region to cytosol

Stable Identifier
R-HSA-429594
Type
Reaction [transition]
Species
Homo sapiens
Compartment
Synonyms
Sodium- and chloride-dependent choline transport by CHT
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The human SLC5A7 gene encodes a sodium- and chloride-dependent, high affinity choline transporter, CHT (Apparsundaram et al. 2000). CHT transports choline (Cho) from the extracellular space into neuronal cells and is dependent on Na+ and Cl- ions for transport (Okuda & Haga 2000). Choline uptake is the rate-limiting step in acetylcholine synthesis.

Literature References
PubMed ID Title Journal Year
11027560 Molecular cloning of a human, hemicholinium-3-sensitive choline transporter

Apparsundaram, S, Ferguson, SM, George AL, Jr, Blakely, RD

Biochem Biophys Res Commun 2000
11068039 Functional characterization of the human high-affinity choline transporter

Okuda, T, Haga, T

FEBS Lett 2000
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
choline transmembrane transporter activity of SLC5A7 [plasma membrane]
Physical Entity
Activity
Orthologous Events
Authored
Reviewed
Created