Reactome | SLC5A5 cotransports Na+ with I- from extracellular region to cytosol

SLC5A5 cotransports Na+ with I- from extracellular region to cytosol

Stable Identifier

R-HSA-429591

Type

Reaction [transition]

Species

Homo sapiens

Compartment

plasma membrane, cytosol, extracellular region

Synonyms

Na+/I- cotransport (influx) by the Na+/I- symporter

ReviewStatus

5/5

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SLC5A5 cotransports Na+ with I- from extracellular region to cytosol

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Human SLC5A5 encodes a Na+/I- symporter, NIS (Smanik et al. 1996). NIS is localized in the basolateral membrane facing the bloodstream and mediates iodide accumulation into thyrocytes. Defects in SLC5A5 cause congenital hypothyroidism due to dyshormonogenesis type 1 (CHDH1) (Fujiwara et al. 1997). NIS, together with AIT (see next reaction), mediates iodide transfer from blood to the colloid lumen of thyrocytes.

Literature References

PubMed ID	Title	Journal	Year
9171822	Congenital hypothyroidism caused by a mutation in the Na+/I- symporter Fujiwara, H, Tatsumi, K, Miki, K, Harada, T, Miyai, K, Takai, S, Amino, N	Nat Genet	1997
8806637	Cloning of the human sodium lodide symporter Smanik, PA, Liu, Q, Furminger, TL, Ryu, K, Xing, S, Mazzaferri, EL, Jhiang, SM	Biochem Biophys Res Commun	1996