SLC5A5 cotransports Na+ with I- from extracellular region to cytosol

Stable Identifier
R-HSA-429591
Type
Reaction [transition]
Species
Homo sapiens
Compartment
Synonyms
Na+/I- cotransport (influx) by the Na+/I- symporter
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Human SLC5A5 encodes a Na+/I- symporter, NIS (Smanik et al. 1996). NIS is localized in the basolateral membrane facing the bloodstream and mediates iodide accumulation into thyrocytes. Defects in SLC5A5 cause congenital hypothyroidism due to dyshormonogenesis type 1 (CHDH1) (Fujiwara et al. 1997). NIS, together with AIT (see next reaction), mediates iodide transfer from blood to the colloid lumen of thyrocytes.

Literature References
PubMed ID Title Journal Year
8806637 Cloning of the human sodium lodide symporter

Smanik, PA, Liu, Q, Furminger, TL, Ryu, K, Xing, S, Mazzaferri, EL, Jhiang, SM

Biochem Biophys Res Commun 1996
9171822 Congenital hypothyroidism caused by a mutation in the Na+/I- symporter

Fujiwara, H, Tatsumi, K, Miki, K, Harada, T, Miyai, K, Takai, S, Amino, N

Nat Genet 1997
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
sodium:iodide symporter activity of SLC5A5 [plasma membrane]
Physical Entity
Activity
Orthologous Events
Authored
Reviewed
Created
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