Reactome | SLC5A6 transports vitamins from extracellular region to cytosol

SLC5A6 transports vitamins from extracellular region to cytosol

Stable Identifier

R-HSA-429581

Type

Reaction [transition]

Species

Homo sapiens

Compartment

plasma membrane

Synonyms

Na+-dependent multivitamin transporter

ReviewStatus

5/5

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SLC5A6 transports vitamins from extracellular region to cytosol

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Biotin (vitamin H or B7) is a water-soluble B-complex vitamin. Biotin is a cofactor in the metabolism of fatty acids and leucine, and it plays a role in gluconeogenesis. D-Pantothoate (vitamin B5), is a water-soluble vitamin needed to form coenzyme-A (CoA), and is critical in the metabolism and synthesis of carbohydrates, proteins, and fats. Lipoic acid is an organosulfur compound, the R-enantiomer of which is an essential cofactor for many enzyme complexes.

The human SLC5A6 encodes the Na+-dependent multivitamin transporter SMVT (Prasad PD et al, 1999; Wang H et al, 1999). SMVT co-transports these vitamins/cofactors into cells with Na+ ions electrogenically. PDZ domain-containing protein 11 (PDZD11 aka AIPP1) is a cytosolic protein with a single PDZ domain which can bind to the C-terminal class 1 PDZ binding motif of SMVT, resulting in a significant induction of vitamin uptake over that with SMVT alone (Nabokina et al. 2011).

Literature References

PubMed ID	Title	Journal	Year
10329687	Human placental Na+-dependent multivitamin transporter. Cloning, functional expression, gene structure, and chromosomal localization. Wang, H, Leibach, FH, Xia, H, Ganapathy, V, Yang-Feng, TL, Huang, W, Devoe, LD, Prasad, PD, Fei, YJ	J Biol Chem	1999
21183659	Association of PDZ-containing protein PDZD11 with the human sodium-dependent multivitamin transporter Said, HM, Nabokina, SM, Subramanian, VS	Am. J. Physiol. Gastrointest. Liver Physiol.	2011
10334869	Molecular and functional characterization of the intestinal Na+-dependent multivitamin transporter Wang, H, Leibach, FH, Ganapathy, V, Huang, W, Devoe, LD, Prasad, PD, Fei, YJ	Arch Biochem Biophys	1999