Co-transport (influx) of myo-inositol/D-chiro-inositol and two Na+ ions by SGLT6

Stable Identifier
R-HSA-429571
Type
Reaction [transition]
Species
Homo sapiens
Compartment
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The human SLC5A11 gene encodes a high affinity myo-inositol transporter (SMIT2, SGLT6) (Ostlund RE et al, 1996; Roll P et al, 2002). It can transport myo-inositol and D-chiro-inositol, together with two Na+ ions. It was thought SGLT6 could transport glucose but there is no evidence for this so far (Lin X et al, 2009).

Literature References
PubMed ID Title Journal Year
8626564 A stereospecific myo-inositol/D-chiro-inositol transporter in HepG2 liver cells. Identification with D-chiro-[3-3H]inositol

Ostlund RE, Jr, Seemayer, R, Gupta, S, Kimmel, R, Ostlund, EL, Sherman, WR

J Biol Chem 1996
12039040 New human sodium/glucose cotransporter gene (KST1): identification, characterization, and mutation analysis in ICCA (infantile convulsions and choreoathetosis) and BFIC (benign familial infantile convulsions) families

Roll, P, Massacrier, A, Pereira, S, Robaglia-Schlupp, A, Cau, P, Szepetowski, P

Gene 2002
19032932 Human sodium/inositol cotransporter 2 (SMIT2) transports inositols but not glucose in L6 cells

Lin, X, Ma, L, Fitzgerald, RL, Ostlund RE, Jr

Arch Biochem Biophys 2009
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
polyol transmembrane transporter activity of SLC5A11 [plasma membrane]
Physical Entity
Activity
Orthologous Events
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