Co-transport (influx) of myo-inositol/D-chiro-inositol and two Na+ ions by SGLT6

Stable Identifier
Reaction [transition]
Homo sapiens
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The human SLC5A11 gene encodes a high affinity myo-inositol transporter (SMIT2, SGLT6) (Ostlund RE et al, 1996; Roll P et al, 2002). It can transport myo-inositol and D-chiro-inositol, together with two Na+ ions. It was thought SGLT6 could transport glucose but there is no evidence for this so far (Lin X et al, 2009).

Literature References
PubMed ID Title Journal Year
12039040 New human sodium/glucose cotransporter gene (KST1): identification, characterization, and mutation analysis in ICCA (infantile convulsions and choreoathetosis) and BFIC (benign familial infantile convulsions) families

Szepetowski, P, Cau, P, Pereira, S, Massacrier, A, Roll, P, Robaglia-Schlupp, A

Gene 2002
8626564 A stereospecific myo-inositol/D-chiro-inositol transporter in HepG2 liver cells. Identification with D-chiro-[3-3H]inositol

Gupta, S, Sherman, WR, Seemayer, R, Kimmel, R, Ostlund, EL, Ostlund RE, Jr

J Biol Chem 1996
19032932 Human sodium/inositol cotransporter 2 (SMIT2) transports inositols but not glucose in L6 cells

Fitzgerald, RL, Lin, X, Ma, L, Ostlund RE, Jr

Arch Biochem Biophys 2009
Catalyst Activity

polyol transmembrane transporter activity of SLC5A11 [plasma membrane]

Orthologous Events
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