Co-transport (influx) of glucose/mannose and Na+ ions by SGLT4

Stable Identifier
R-HSA-429567
Type
Reaction [transition]
Species
Homo sapiens
Compartment
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The human gene SLC5A9 encodes a low affinity transporter for glucose and mannose (SGLT4). Of the tissues tested, SGLT4 appears to be highly expressed in the kidney and intestine, with lower levels detected in the liver. Human SGLT4 expressed in african green monkey cells exhibited glucose and mannose co-transport with Na+ ions (Tazawa S et al, 2005).

Literature References
PubMed ID Title Journal Year
15607332 SLC5A9/SGLT4, a new Na+-dependent glucose transporter, is an essential transporter for mannose, 1,5-anhydro-D-glucitol, and fructose

Tazawa, S, Yamato, T, Fujikura, H, Hiratochi, M, Itoh, F, Tomae, M, Takemura, Y, Maruyama, H, Sugiyama, T, Wakamatsu, A, Isogai, T, Isaji, M

Life Sci 2005
Participants
Participates
Catalyst Activity

low-affinity glucose:sodium symporter activity of SLC5A9 [plasma membrane]

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