Reactome | Co-transport (influx) of glucose/mannose and Na+ ions by SGLT4

Co-transport (influx) of glucose/mannose and Na+ ions by SGLT4

Stable Identifier

R-HSA-429567

Type

Reaction [transition]

Species

Homo sapiens

Compartment

plasma membrane

ReviewStatus

5/5

Locations in the PathwayBrowser

Expand all

General

SBML | | PDF

SVG | | PPTX | SBGN

Co-transport (influx) of glucose/mannose and Na+ ions by SGLT4

Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

The human gene SLC5A9 encodes a low affinity transporter for glucose and mannose (SGLT4). Of the tissues tested, SGLT4 appears to be highly expressed in the kidney and intestine, with lower levels detected in the liver. Human SGLT4 expressed in african green monkey cells exhibited glucose and mannose co-transport with Na+ ions (Tazawa S et al, 2005).

Literature References

PubMed ID	Title	Journal	Year
15607332	SLC5A9/SGLT4, a new Na+-dependent glucose transporter, is an essential transporter for mannose, 1,5-anhydro-D-glucitol, and fructose Tazawa, S, Yamato, T, Fujikura, H, Hiratochi, M, Itoh, F, Tomae, M, Takemura, Y, Maruyama, H, Sugiyama, T, Wakamatsu, A, Isogai, T, Isaji, M	Life Sci	2005