SLC2A9 transports Fru, Glc, urate

Stable Identifier
R-HSA-429036
Type
Reaction [transition]
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
General
SVG |   | PPTX  | SBGN
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

The human SLC2A9 gene encodes two isoforms of class II facilitative glucose transporter 9; GLUT9 (Phay et al. 2000) and GLUT9DeltaN (Augustin et al. 2004). GLUT9 is expressed mainly in kidney (proximal tubules of epithelial cells) and liver while GLUT9DeltaN is expressed mainly in kidney and placenta. SLC2A9 mediates the transport of urate (uric acid), the end product of purine metabolism in humans and great apes. In addition it mediates the uptake of fructose (Fru) and glucose (Glc) at a low rate (Vitart et al. 2008). Mutations in SLC2A9 influence serum urate concentrations with excess serum accumulation of urate leading to the development of gout (Vitart et al. 2008).

Literature References
PubMed ID Title Journal Year
10860667 Cloning and expression analysis of a novel member of the facilitative glucose transporter family, SLC2A9 (GLUT9)

Phay, JE, Hussain, HB, Moley, JF

Genomics 2000
18327257 SLC2A9 is a newly identified urate transporter influencing serum urate concentration, urate excretion and gout

Vitart, V, Rudan, I, Hayward, C, Gray, NK, Floyd, J, Palmer, CN, Knott, SA, Kolcic, I, Polasek, O, Graessler, J, Wilson, JF, Marinaki, A, Riches, PL, Shu, X, Janicijevic, B, Smolej-Narancic, N, Gorgoni, B, Morgan, J, Campbell, S, Biloglav, Z, Barac-Lauc, L, Pericic, M, Klaric, IM, Zgaga, L, Skaric-Juric, T, Wild, SH, Richardson, WA, Hohenstein, P, Kimber, CH, Tenesa, A, Donnelly, LA, Fairbanks, LD, Aringer, M, McKeigue, PM, Ralston, SH, Morris, AD, Rudan, P, Hastie, ND, Campbell, H, Wright, AF

Nat Genet 2008
14739288 Identification and characterization of human glucose transporter-like protein-9 (GLUT9): alternative splicing alters trafficking

Augustin, R, Carayannopoulos, MO, Dowd, LO, Phay, JE, Moley, JF, Moley, KH

J Biol Chem 2004
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
transmembrane transporter activity of SLC2A9 [plasma membrane]
Physical Entity
Activity
Orthologous Events
Cross References
Rhea
Authored
Reviewed
Created
Cite Us!