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ALOX5 [cytosol]
Stable Identifier
R-HSA-429010
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
cytosol
Synonyms
Arachidonate 5-lipoxygenase, LOX5_HUMAN
Locations in the PathwayBrowser for interactor UniProt:P50221%20MEOX1
Expand all
Metabolism (Homo sapiens)
Metabolism of lipids (Homo sapiens)
Biosynthesis of specialized proresolving mediators (SPMs) (Homo sapiens)
Biosynthesis of DHA-derived SPMs (Homo sapiens)
Biosynthesis of D-series resolvins (Homo sapiens)
ALOX5 dehydrogenates 4(S)-Hp-17(S)-HDHA to 4S(5)-epoxy-17(S)-HDHA (Homo sapiens)
ALOX5 [cytosol] (Homo sapiens)
ALOX5 dehydrogenates 7(S)-Hp-17(S)-HDHA to 7S(8)-epoxy-17S-HDHA (Homo sapiens)
ALOX5 [cytosol] (Homo sapiens)
ALOX5 oxidises 17(S)-HDHA to 4(S)-Hp-17(S)-HDHA (Homo sapiens)
ALOX5 [cytosol] (Homo sapiens)
ALOX5 oxidises 17(S)-HDHA to 7(S)-Hp-17(S)-HDHA (Homo sapiens)
ALOX5 [cytosol] (Homo sapiens)
Biosynthesis of aspirin-triggered D-series resolvins (Homo sapiens)
ALOX5 dehydrogenates 4(S)-Hp-17(R)-HDHA to 4S(5)-epoxy-17(R)-HDHA (Homo sapiens)
ALOX5 [cytosol] (Homo sapiens)
ALOX5 dehydrogenates 7(S)-Hp-17R-HDHA to 7S(8)-epoxy-17R-HDHA (Homo sapiens)
ALOX5 [cytosol] (Homo sapiens)
ALOX5 oxidises 17(R)-HDHA to 4(S)-Hp-17(R)-HDHA (Homo sapiens)
ALOX5 [cytosol] (Homo sapiens)
ALOX5 oxidises 17(R)-HDHA to 7(S)-Hp-17(R)-HDHA (Homo sapiens)
ALOX5 [cytosol] (Homo sapiens)
Biosynthesis of maresins (Homo sapiens)
ALOX5 oxidises 14(S)-Hp-DHA to 7(S),14(S)-diHp-DHA (Homo sapiens)
ALOX5 [cytosol] (Homo sapiens)
Biosynthesis of DPA-derived SPMs (Homo sapiens)
Biosynthesis of DPAn-3 SPMs (Homo sapiens)
Biosynthesis of DPAn-3-derived 13-series resolvins (Homo sapiens)
ALOX5 oxidises 13(R)-HDPAn-3 to RvT1-4 (Homo sapiens)
ALOX5 [cytosol] (Homo sapiens)
Biosynthesis of DPAn-3-derived maresins (Homo sapiens)
ALOX5 oxidises 14(S)-Hp-DPAn-3 to MaR3n-3 DPA (Homo sapiens)
ALOX5 [cytosol] (Homo sapiens)
Biosynthesis of DPAn-3-derived protectins and resolvins (Homo sapiens)
ALOX5 dehydrogenates 17(S)-Hp-DPAn-3 to 16(S),17(S)-epoxy-DPAn-3 (Homo sapiens)
ALOX5 [cytosol] (Homo sapiens)
ALOX5 dehydrogenates 7,17-diHp-DPAn-3 to 7,8-epoxy,17-HDPAn-3 (Homo sapiens)
ALOX5 [cytosol] (Homo sapiens)
ALOX5 oxidises 17(S)-Hp-DPAn-3 to 7,17-diHp-DPAn-3 (Homo sapiens)
ALOX5 [cytosol] (Homo sapiens)
Biosynthesis of EPA-derived SPMs (Homo sapiens)
Biosynthesis of E-series 18(R)-resolvins (Homo sapiens)
ALOX5 oxidises 18(R)-HEPE to 5(S)-Hp-18(R)-HEPE (Homo sapiens)
ALOX5 [cytosol] (Homo sapiens)
ALOX5 oxidises 5(S)-Hp-18(R)-HEPE to 5S,6S-epoxy-18(R)-HEPE (Homo sapiens)
ALOX5 [cytosol] (Homo sapiens)
Biosynthesis of E-series 18(S)-resolvins (Homo sapiens)
ALOX5 oxidises 18(S)-HEPE to 5(S)-Hp-18(S)-HEPE (Homo sapiens)
ALOX5 [cytosol] (Homo sapiens)
ALOX5 oxidises 5(S)-Hp-18(S)-HEPE to 5S,6S-epoxy-18(S)-HEPE (Homo sapiens)
ALOX5 [cytosol] (Homo sapiens)
Biosynthesis of electrophilic ω-3 PUFA oxo-derivatives (Homo sapiens)
ALOX5 oxidises DHA to 7-HDHA (Homo sapiens)
ALOX5 [cytosol] (Homo sapiens)
ALOX5 oxidises DPAn-3 to 7-HDPAn-3 (Homo sapiens)
ALOX5 [cytosol] (Homo sapiens)
ALOX5 oxidises EPA to 5-HEPE (Homo sapiens)
ALOX5 [cytosol] (Homo sapiens)
External Reference Information
External Reference
UniProt:P09917 ALOX5
Gene Names
ALOX5, LOG5
Chain
chain:1-674
Reference Genes
BioGPS Gene:240 ALOX5
COSMIC (genes):ALOX5 ALOX5
CTD Gene:240 ALOX5
dbSNP Gene:240 ALOX5
ENSEMBL:ENSG00000012779 ALOX5
ENSEMBL_homo_sapiens_GENE:ENSG00000012779.12 ALOX5
ENSEMBL_homo_sapiens_GENE:ENSG00000275565.4 ALOX5
HGNC:435 ALOX5
KEGG Gene (Homo sapiens):240 ALOX5
Monarch:240 ALOX5
NCBI Gene:240 ALOX5
OMIM:152390 ALOX5
UCSC:P09917 ALOX5
Reference Transcript
RefSeq:NM_000698.4 ALOX5
RefSeq:NM_001256154.2 ALOX5
RefSeq:NM_001320861.1 ALOX5
RefSeq:NM_001256153.2 ALOX5
Other Identifiers
11726337_a_at
11726338_a_at
16704375
204445_PM_s_at
204445_s_at
204446_PM_s_at
204446_s_at
214366_PM_s_at
214366_s_at
240
307_at
3244623
3244624
3244627
3244628
3244630
3244634
3244635
3244640
3244649
3244650
3244653
3244655
3244656
3244659
3244661
3244662
3244663
7927215
A_14_P104436
A_23_P104464
GE57484
GO:0001676
GO:0001937
GO:0002232
GO:0002376
GO:0002523
GO:0002540
GO:0003824
GO:0004051
GO:0004052
GO:0005506
GO:0005515
GO:0005576
GO:0005615
GO:0005634
GO:0005635
GO:0005641
GO:0005654
GO:0005737
GO:0005829
GO:0006629
GO:0006690
GO:0006691
GO:0006954
GO:0006959
GO:0007155
GO:0016020
GO:0016363
GO:0016491
GO:0016525
GO:0016702
GO:0016787
GO:0019369
GO:0019370
GO:0019372
GO:0023052
GO:0030154
GO:0030501
GO:0031410
GO:0031965
GO:0034440
GO:0034774
GO:0036336
GO:0036403
GO:0042060
GO:0042593
GO:0042759
GO:0043226
GO:0043651
GO:0045598
GO:0046872
GO:0048471
GO:0048856
GO:0048870
GO:0050727
GO:0050728
GO:0050796
GO:0051122
GO:0051213
GO:0061044
GO:0061045
GO:0106014
GO:1900015
GO:1900407
GO:1901753
GO:1903426
GO:1903573
GO:1903671
GO:1904813
GO:1904999
GO:2001301
HMNXSV003035123
Hs.89499.0.A1_3p_a_at
Hs.89499.2.S1_3p_a_at
ILMN_1680996
ILMN_1792150
J03600_at
TC10000293.hg
g4502056_3p_a_at
Participates
as a component of
ALOX5:Ca2+:Fe2+ [cytosol] (Homo sapiens)
as a member of
IL18, ALOX5 [cytosol] (Homo sapiens)
Other forms of this molecule
p-S272-ALOX5 [cytosol]
ALOX5 [secretory granule lumen]
ALOX5 [extracellular region]
ALOX5 [ficolin-1-rich granule lumen]
p-S272-ALOX5 [nuclear envelope]
Inferred To
lipA [cytosol]
(Dictyostelium discoideum)
ALOX5 [cytosol]
(Bos taurus)
ALOX5 [cytosol]
(Canis familiaris)
ALOX5 [cytosol]
(Danio rerio)
ALOX5 [cytosol]
(Gallus gallus)
ALOX5 [cytosol]
(Mus musculus)
ALOX5 [cytosol]
(Rattus norvegicus)
ALOX5 [cytosol]
(Sus scrofa)
ALOX5 [cytosol]
(Xenopus tropicalis)
Homologues of ALOX5 [cytosol]
(Danio rerio)
Cross References
RefSeq
NP_000689.1
,
NP_001243083.1
,
NP_001307790.1
,
NP_001243082.1
ZINC - World Drugs
LOX5_HUMAN
Guide to Pharmacology - Targets
1385
OpenTargets
ENSG00000012779
ZINC - FDA approved
LOX5_HUMAN
ZINC - Substances
LOX5_HUMAN
ZINC - Biogenic
LOX5_HUMAN
ZINC target
P09917
PRO
P09917
PDB
7TTJ
,
3O8Y
,
7TTL
,
7TTK
,
6N2W
,
3V98
,
3V92
,
3V99
,
6NCF
ZINC - Investigational
LOX5_HUMAN
ZINC - Metabolites
LOX5_HUMAN
IntEnz
1.13.11.34
GeneCards
P09917
HPA
ENSG00000012779-ALOX5
Ensembl
ENSG00000012779
,
ENSP00000484468
,
ENSG00000275565
,
ENST00000374391
,
ENST00000542434
,
ENST00000622021
,
ENSP00000437634
,
ENSP00000363512
,
ENST00000610656
,
ENSP00000479958
Pharos - Targets
P09917
ZINC - Predictions - Purchasable
LOX5_HUMAN
HMDB Protein
HMDBP00972
Interactors (21)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q9Y6D9 MAD1L1
1
MAD1L1 [cytosol]
(R-HSA-141433)
0.805
9
UniProt:Q96MT8-3 CEP63
0.718
8
UniProt:Q6UWX4 HIPL2
0.718
6
UniProt:Q8N0S2 SYCE1
1
SYCE1 [nucleoplasm]
(R-HSA-912456)
0.718
6
UniProt:Q14019 COTL1
3
COTL1 [secretory granule lumen]
(R-HSA-6801366)
COTL1 [extracellular region]
(R-HSA-6806475)
COTL1 [ficolin-1-rich granule lumen]
(R-HSA-6801386)
0.698
5
UniProt:Q96MT8 CEP63
1
CEP63 [cytosol]
(R-HSA-380267)
0.666
4
UniProt:Q86Y26 NUTM1
0.666
4
UniProt:Q8IYJ2-2 C10ORF67
0.556
3
UniProt:Q7Z699 SPRED1
2
SPRED1 [plasma membrane]
(R-HSA-5658225)
SPRED1 [cytosol]
(R-HSA-5654207)
0.556
3
UniProt:Q6PII3 CC174
0.556
3
UniProt:Q6P2R3 Q6P2R3
0.556
3
IntAct:EBI-22314709 CCSB ORF ID
0.556
3
UniProt:Q04864 REL
2
REL [cytosol]
(R-HSA-1168579)
REL [nucleoplasm]
(R-HSA-1168585)
0.556
3
UniProt:P31025 LCN1
1
LCN1 [extracellular region]
(R-HSA-5229284)
0.556
3
UniProt:O43716 GATC
0.556
6
UniProt:Q6FHY5 Q6FHY5
0.556
3
UniProt:A6NGQ2 OOEP
0.556
3
UniProt:P50221 MEOX1
0.556
3
UniProt:Q8IYX8-2 CEP57L1
0.556
3
UniProt:P14061 HSD17B1
2
HSD17B1 [cytosol]
(R-HSA-804968)
HSD17B1 [photoreceptor outer segment membrane]
(R-HSA-4127422)
0.556
3
UniProt:Q9P0N9 TBC1D7
1
TBC1D7 [cytosol]
(R-HSA-8854154)
0.556
3
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