Phosphorylation of cPLA2 by MAPK p38 alpha

Stable Identifier
R-HSA-428961
Type
Reaction [transition]
Species
Homo sapiens
Compartment
cytosol, endoplasmic reticulum membrane
ReviewStatus
5/5
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Phosphorylation of cPLA2 by MAPK p38 alpha
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MAPK p38 alpha activates cPLA2 by phosphorylation of two serine residues.
cPLA2 can be phosphorylated and activated by ERK2 (Lin et al. 1993), and were believed to be responsible for the phosphorylation of cPLA2. However, phosphorylation of cPLA2 occurred in the absence of ERK activation in human platelets stimulated with the thrombin receptor agonist peptide SFLLRN (Kramer et al. 1995), and cPLA2 phosphorylation induced by thrombin or collagen was unaffected by PKC inhibitors that prevent ERK activation (Börsch-Haubold et al. 1995). In addition, a specific inhibitor of ERKs did not block thrombin-induced cPLA2 phosphorylation (Börsch-Haubold et al. 1996).
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as an event of
Catalyst Activity

protein serine/threonine kinase activity of p-T180,Y182-MAPK14 [cytosol]

Physical Entity
p-T180,Y182-MAPK14 [cytosol] (Homo sapiens)
Activity
protein serine/threonine kinase activity (GO:0004674)
Orthologous Events
Phosphorylation of cPLA2 by MAPK p38 alpha (Bos taurus)
Phosphorylation of cPLA2 by MAPK p38 alpha (Canis familiaris)
Phosphorylation of cPLA2 by MAPK p38 alpha (Danio rerio)
Phosphorylation of cPLA2 by MAPK p38 alpha (Dictyostelium discoideum)
Phosphorylation of cPLA2 by MAPK p38 alpha (Gallus gallus)
Phosphorylation of cPLA2 by MAPK p38 alpha (Mus musculus)
Phosphorylation of cPLA2 by MAPK p38 alpha (Rattus norvegicus)
Phosphorylation of cPLA2 by MAPK p38 alpha (Saccharomyces cerevisiae)
Phosphorylation of cPLA2 by MAPK p38 alpha (Schizosaccharomyces pombe)
Phosphorylation of cPLA2 by MAPK p38 alpha (Sus scrofa)
Phosphorylation of cPLA2 by MAPK p38 alpha (Xenopus tropicalis)
Authored
Akkerman, JW  (2009-06-03)
Reviewed
Poole, AW  (2009-11-02)
Jones, ML  (2009-11-02)
Harper, MT  (2009-11-02)
Created
Jupe, S  (2009-07-13)
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