P2Y purinoceptor 1 activates MAP kinase p38 alpha

Stable Identifier
R-HSA-428941
Type
Reaction [omitted]
Species
Homo sapiens
Compartment
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ADP activates human platelets and induces endothelial cell migration. These effects are partly mediated by the P2Y1 purinocetor, inducing p38 MAP kinase activation via an uncharacterised factor. Possible mechanisms include flotillin-mediated stimulation of SRC family kinases in lipid rafts (Sugawara et al. 2007).

Literature References
PubMed ID Title Journal Year
10759852 The P2Y1 receptor mediates ADP-induced p38 kinase-activating factor generation in human platelets

Dangelmaier, C, Jin, J, Daniel, JL, Smith, JB, Kunapuli, SP

Eur J Biochem 2000
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
GTPase activity of G-protein alpha (q/11): GTP [plasma membrane]
Physical Entity
Activity
Orthologous Events
Authored
Reviewed
Created