P2Y purinoceptor 1 activates MAP kinase p38 alpha

Stable Identifier
R-HSA-428941
Type
Reaction [BlackBoxEvent]
Species
Homo sapiens
Compartment
cytosol
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P2Y purinoceptor 1 activates MAP kinase p38 alpha
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ADP activates human platelets and induces endothelial cell migration. These effects are partly mediated by the P2Y1 purinocetor, inducing p38 MAP kinase activation via an uncharacterised factor. Possible mechanisms include flotillin-mediated stimulation of SRC family kinases in lipid rafts (Sugawara et al. 2007).

Literature References
PubMed ID Title Journal Year
10759852 The P2Y1 receptor mediates ADP-induced p38 kinase-activating factor generation in human platelets

Smith, JB, Jin, J, Dangelmaier, C, Kunapuli, SP, Daniel, JL

Eur J Biochem 2000
Participants
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Output
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as an event of
Catalyst Activity

GTPase activity of G-protein alpha (q/11): GTP [plasma membrane]

Physical Entity
G-protein alpha (q/11): GTP [plasma membrane] (Homo sapiens)
Activity
GTPase activity (GO:0003924)
Orthologous Events
P2Y purinoceptor 1 activates MAP kinase p38 alpha (Bos taurus)
P2Y purinoceptor 1 activates MAP kinase p38 alpha (Caenorhabditis elegans)
P2Y purinoceptor 1 activates MAP kinase p38 alpha (Canis familiaris)
P2Y purinoceptor 1 activates MAP kinase p38 alpha (Danio rerio)
P2Y purinoceptor 1 activates MAP kinase p38 alpha (Drosophila melanogaster)
P2Y purinoceptor 1 activates MAP kinase p38 alpha (Gallus gallus)
P2Y purinoceptor 1 activates MAP kinase p38 alpha (Mus musculus)
P2Y purinoceptor 1 activates MAP kinase p38 alpha (Rattus norvegicus)
P2Y purinoceptor 1 activates MAP kinase p38 alpha (Saccharomyces cerevisiae)
P2Y purinoceptor 1 activates MAP kinase p38 alpha (Schizosaccharomyces pombe)
P2Y purinoceptor 1 activates MAP kinase p38 alpha (Sus scrofa)
Authored
Akkerman, JW  (2009-06-03)
Reviewed
Harper, MT  (2009-11-02)
Jones, ML  (2009-11-02)
Poole, AW  (2009-11-02)
Created
Jupe, S  (2009-07-13)
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