p-T180,Y182-MAPK14 [cytosol]

Stable Identifier
R-HSA-428935
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
cytosol
Synonyms
Phospho-MAP kinase p38 alpha, MAP kinase p38 alpha (activated), MAPK14, Mitogen-activated protein kinase 14, MK14_HUMAN, pp38 alpha
Icon
p-T180,Y182-MAPK14 [cytosol] icon
p-T180,Y182-MAPK14 [cytosol] icon
Locations in the PathwayBrowser for interactor UniProt:P52564 MAP2K6
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External Reference Information
External Reference
UniProt:Q16539 MAPK14
Gene Names
MAPK14, CSBP, CSBP1, CSBP2, CSPB1, MXI2, SAPK2A
Chain
initiator methionine:, chain:2-360
Reference Genes
BioGPS Gene:1432 MAPK14
COSMIC (genes):MAPK14 MAPK14
CTD Gene:1432 MAPK14
dbSNP Gene:1432 MAPK14
ENSEMBL:ENSG00000112062 MAPK14
HGNC:6876 MAPK14
KEGG:hsa:1432 MAPK14
Monarch:1432 MAPK14
NCBI Gene:1432 MAPK14
OMIM:600289 MAPK14
UCSC:Q16539 MAPK14
Reference Transcript
Participates
as a member of
as a candidate of
as an output of
Other forms of this molecule
p-T180,Y182-MAPK14 [nucleoplasm]
MAPK14 [cytosol]
MAPK14 [nucleoplasm]
MAPK14 [ficolin-1-rich granule lumen]
MAPK14 [extracellular region]
MAPK14 [secretory granule lumen]
Inferred To
phospho-p38b [cytosol] (Drosophila melanogaster)
phospho-mapk14b [cytosol] (Danio rerio)
phospho-Mapk14 [cytosol] (Rattus norvegicus)
phospho-p38a [cytosol] (Drosophila melanogaster)
phospho-p38c [cytosol] (Drosophila melanogaster)
Homologues of p-T180,Y182-MAPK14 [cytosol] (Caenorhabditis elegans)
Homologues of p-T180,Y182-MAPK14 [cytosol] (Dictyostelium discoideum)
Homologues of p-T180,Y182-MAPK14 [cytosol] (Drosophila melanogaster)
phospho-gskl-2 [cytosol] (Caenorhabditis elegans)
phospho-mapk14 [cytosol] (Xenopus tropicalis)
phospho-MAP kinase p38 alpha [cytosol] (Mus musculus)
phospho-MAPK14 [cytosol] (Bos taurus)
phospho-MAPK14 [cytosol] (Gallus gallus)
phospho-MAPK14 [cytosol] (Sus scrofa)
phospho-sty1 [cytosol] (Schizosaccharomyces pombe)
phospho-pmk-2 [cytosol] (Caenorhabditis elegans)
phospho-p-T180,Y182-MAPK14 [cytosol] (Caenorhabditis elegans)
phospho-p-T180,Y182-MAPK14 [cytosol] (Canis familiaris)
phospho-p-T180,Y182-MAPK14 [cytosol] (Dictyostelium discoideum)
phospho-HOG1 [cytosol] (Saccharomyces cerevisiae)
phospho-cdc7 [cytosol] (Dictyostelium discoideum)
phospho-pmk-3 [cytosol] (Caenorhabditis elegans)
phospho-pmk-1 [cytosol] (Caenorhabditis elegans)
Modified Residues
Name
O-phospho-L-threonine at 180
Coordinate
180
PsiMod Name
O-phospho-L-threonine [MOD:00047]
PsiMod Definition
A protein modification that effectively converts an L-threonine residue to O-phospho-L-threonine.
Name
O4'-phospho-L-tyrosine at 182
Coordinate
182
PsiMod Name
O4'-phospho-L-tyrosine [MOD:00048]
PsiMod Definition
A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.
Cross References
RefSeq
ZINC - World Drugs
Guide to Pharmacology - Targets
OpenTargets
ENSEMBL
ZINC - FDA approved
ZINC - Substances
ZINC - Biogenic
ZINC target
PRO
GlyGen
PDB
3HP5, 5XYX, 4EWQ, 1WBN, 4EH3, 3FMN, 3MVM, 2LGC, 1WFC, 1ZYJ, 3ROC, 4KIN, 3HV3, 3CTQ, 4EH7, 4F9W, 5N66, 5OMG, 2BAQ, 3OC1, 6HWV, 3OBJ, 3NEW, 3OCG, 6M95, 4E5A, 4AAC, 5WJJ, 3IW8, 3ODY, 3GI3, 2YIX, 3D83, 5MTY, 3L8S, 5ETI, 2QD9, 4L8M, 3O8P, 3FKN, 3IPH, 3S4Q, 1W84, 3HEC, 5N65, 3FMK, 3L8X, 3FLZ, 3MPT, 6HWU, 3MW1, 3UVP, 4AA4, 3GCP, 3GFE, 4E5B, 1YQJ, 3NNW, 3ODZ, 3BX5, 3KQ7, 2Y8O, 3FMM, 3FMH, 4EHV, 3MVL, 2ONL, 5N63, 4EH6, 3IW6, 3OEF, 2YIS, 3GCV, 6TCA, 4A9Y, 8A8M, 3LFE, 3FKL, 4E6A, 6QE1, 3GC7, 3E92, 3MH2, 3HUB, 2YIW, 3U8W, 5N67, 3FC1, 4ZTH, 5ETF, 2GFS, 5TCO, 1R39, 3LFD, 3GCU, 3O8U, 3NNU, 4GEO, 5XYY, 3C5U, 1WBS, 5ETA, 3FLQ, 3IW7, 1WBV, 3DT1, 3LFF, 3FLY, 3FMJ, 1BL6, 9CJ3, 3E93, 3MH3, 6ANL, 3MGY, 6QDZ, 3HUC, 6QYX, 3KF7, 3HV6, 1R3C, 1IAN, 1M7Q, 3NWW, 3OD6, 3NNV, 3FSF, 6OHD, 1OUY, 3LHJ, 1WBO, 3ZYA, 3HEG, 2FSO, 3FLN, 1KV1, 1OUK, 8VXE, 3LFC, 2RG6, 3FLW, 3ITZ, 3HV5, 3FI4, 5TBE, 4F9Y, 3MH0, 3BV3, 3GCS, 3HP2, 1A9U, 5ETC, 4DLI, 6SFK, 2BAK, 4R3C, 6RFO, 9CJ5, 4AA0, 3HA8, 4EH5, 3IW5, 5N64, 2ZAZ, 6M9L, 3S3I, 3O8T, 9CJ2, 1WBW, 2RG5, 2OKR, 1BL7, 3OBG, 3ZSH, 3UVR, 3MH1, 3ZS5, 5OMH, 4EH2, 1DI9, 1BMK, 3HRB, 3RIN, 3MPA, 5MZ3, 3HL7, 4DLJ, 2BAJ, 8X3M, 6SFO, 6ZWP, 3HV7, 4EH4, 3FLS, 1ZZ2, 2NPQ, 2FSM, 5O8U, 1W7H, 1WBT, 3K3I, 3ZSI, 1ZZL, 1W83, 3LFA, 3HV4, 5O8V, 4KIP, 4EH8, 5ML5, 3HLL, 3FL4, 4AA5, 3GCQ, 2ZB0, 6SFJ, 3NNX, 3QUD, 2BAL, 3PG3, 6ZQS, 2I0H, 9CJ4, 5MTX, 1KV2, 2FST, 2FSL, 6HWT, 3FKO, 4E6C, 3K3J, 1OZ1, 3LFB, 1W82, 9CJ1, 4FA2, 3D7Z, 4E8A, 5N68, 3FML, 3UVQ, 3ZSG, 3BV2, 4EH9, 4KIQ, 3HVC, 2ZB1, 1OVE, 6SFI, 3QUE, 3FSK, 3DS6
ZINC - Investigational
ZINC - Metabolites
IntEnz
GeneCards
HPA
Pharos - Targets
ZINC - Predictions - Purchasable
HMDB Protein
Interactors (39)
Accession #Entities Entities Confidence Score Evidence (IntAct)
 UniProt:P49137 MAPKAPK2  5 0.936 16
 UniProt:Q16644 MAPKAPK3  4 0.922 16
 UniProt:O75676 RPS6KA4  1 0.869 10
 UniProt:P46734 MAP2K3  3 0.802 7
 UniProt:Q9BUB5 MKNK1  1 0.798 7
 UniProt:O75147 OBSL1  1 0.788 5
 UniProt:Q9HBH9 MKNK2      0.788 5
 UniProt:Q99956 DUSP9  1 0.779 6
 UniProt:P28562 DUSP1  1 0.767 4
 UniProt:Q8NEM7 SUPT20H  1 0.756 5
 UniProt:Q9BY84 DUSP16  3 0.738 4
 UniProt:O43257 ZNHI1      0.72 7
 UniProt:Q15750 TAB1  6 0.713 4
 UniProt:P27361 MAPK3  6 0.691 5
 UniProt:Q15256 PTPRR      0.664 4
 UniProt:O75582 RPS6KA5  3 0.659 4
 UniProt:Q6PJG2 MDEAS      0.659 3
 UniProt:P46940 IQGAP1  3 0.643 4
 UniProt:Q9H0W5 CCDC8  1 0.643 3
 UniProt:P06400 RB1  20 0.623 4
 UniProt:Q16829 DUSP7  2 0.59 2
 UniProt:P52564 MAP2K6  3 0.564 3
 UniProt:P48730-2 CSNK1D      0.556 3
 UniProt:Q9H869 YYAP1      0.553 2
 UniProt:Q8IW41 MAPKAPK5  5 0.547 2
 UniProt:Q14814 MEF2D  1 0.547 2
 UniProt:Q15759 MAPK11  4 0.547 2
 UniProt:P68104 EEF1A1  7 0.547 3
 UniProt:P13639 EEF2  10 0.527 2
 UniProt:Q5VYV7 SLX4I      0.527 3
 UniProt:Q14999 CUL7  1 0.527 2
 UniProt:Q96RR4 CAMKK2  4 0.527 2
 UniProt:Q96CC6 RHDF1      0.527 2
 UniProt:Q15170 TCAL1      0.527 2
 UniProt:P78368 CSNK1G2  2 0.527 3
 UniProt:P51784 USP11  1 0.527 2
 UniProt:Q07352 ZFP36L1  3 0.508 2
 UniProt:Q92574 TSC1  2 0.508 2
 UniProt:Q969H0 FBXW7  1 0.471 5
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