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Thromboxane signalling through TP receptor
Stable Identifier
R-HSA-428930
Type
Pathway
Species
Homo sapiens
Compartment
plasma membrane
ReviewStatus
5/5
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Hemostasis (Homo sapiens)
Platelet activation, signaling and aggregation (Homo sapiens)
Signal amplification (Homo sapiens)
Thromboxane signalling through TP receptor (Homo sapiens)
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Thromboxane (TXA2) binds to the thromboxane receptor (TP). There are 2 splice variant forms of TP, differing in their cytoplasmic carboxyl terminal tails. TP beta was first identified in endothelial cells. TP alpha was identified in platelets and placenta. The major signalling route for TP is Gq-mediated stimulation of PLC and consequent increase in cellular calcium. TP also couples to G13, leading to stimulation of Rho and Rac.
Literature References
PubMed ID
Title
Journal
Year
18374420
Thromboxane A2: physiology/pathophysiology, cellular signal transduction and pharmacology
Nakahata, N
Pharmacol Ther
2008
Participants
Events
AAMP binds to TBXA2R
(Homo sapiens)
TP receptor can bind thromboxane
(Homo sapiens)
Activated TP receptor binds G-proten Gq
(Homo sapiens)
Activated TP receptor binds G-protein G13
(Homo sapiens)
Gq activation by TP receptor
(Homo sapiens)
G13 activation by TP receptor
(Homo sapiens)
Dissociation of the TP:Gq complex
(Homo sapiens)
Dissociation of the TP:G13 complex
(Homo sapiens)
Participates
as an event of
Signal amplification (Homo sapiens)
Orthologous Events
Thromboxane signalling through TP receptor (Bos taurus)
Thromboxane signalling through TP receptor (Caenorhabditis elegans)
Thromboxane signalling through TP receptor (Canis familiaris)
Thromboxane signalling through TP receptor (Danio rerio)
Thromboxane signalling through TP receptor (Drosophila melanogaster)
Thromboxane signalling through TP receptor (Gallus gallus)
Thromboxane signalling through TP receptor (Mus musculus)
Thromboxane signalling through TP receptor (Rattus norvegicus)
Thromboxane signalling through TP receptor (Sus scrofa)
Thromboxane signalling through TP receptor (Xenopus tropicalis)
Cross References
BioModels Database
BIOMD0000000088
Authored
Akkerman, JW (2009-06-03)
Reviewed
Harper, MT (2009-11-02)
Jones, ML (2009-11-02)
Poole, AW (2009-11-02)
Created
Jupe, S (2009-07-13)
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