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Activated TP receptor binds G-protein G13
Stable Identifier
R-HSA-428909
Type
Reaction [binding]
Species
Homo sapiens
Compartment
plasma membrane
ReviewStatus
5/5
Locations in the PathwayBrowser
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Hemostasis (Homo sapiens)
Platelet activation, signaling and aggregation (Homo sapiens)
Signal amplification (Homo sapiens)
Thromboxane signalling through TP receptor (Homo sapiens)
Activated TP receptor binds G-protein G13 (Homo sapiens)
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The thromboxane receptor (TP) can activate G12 and G13.
Literature References
PubMed ID
Title
Journal
Year
16418336
The G12 family of G proteins as a reporter of thromboxane A2 receptor activity
Kim, D
,
Zhang, L
,
Manning, DR
,
Smyth, EM
,
DiLizio, C
Mol Pharmacol
2006
16212421
Coupling interaction between thromboxane A2 receptor and alpha-13 subunit of guanine nucleotide-binding protein
Chou, KC
J Proteome Res
2005
Participants
Input
Heterotrimeric G-protein G13 (inactive) [plasma membrane]
(Homo sapiens)
TBXA2R:TXA2 [plasma membrane]
(Homo sapiens)
Output
TP receptor:Thromboxane A2:G-protein G13 (inactive) [plasma membrane]
(Homo sapiens)
Participates
as an event of
Thromboxane signalling through TP receptor (Homo sapiens)
Orthologous Events
Activated TP receptor binds G-protein G13 (Bos taurus)
Activated TP receptor binds G-protein G13 (Canis familiaris)
Activated TP receptor binds G-protein G13 (Drosophila melanogaster)
Activated TP receptor binds G-protein G13 (Gallus gallus)
Activated TP receptor binds G-protein G13 (Mus musculus)
Activated TP receptor binds G-protein G13 (Sus scrofa)
Activated TP receptor binds G-protein G13 (Xenopus tropicalis)
Authored
Akkerman, JW (2009-06-03)
Reviewed
Harper, MT (2009-11-02)
Jones, ML (2009-11-02)
Poole, AW (2009-11-02)
Created
Jupe, S (2009-07-13)
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