Phosphorylation of ROBO1 by ABL kinase

Stable Identifier
R-HSA-428888
Type
Reaction [transition]
Species
Homo sapiens
Compartment
cytosol, plasma membrane
ReviewStatus
5/5
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Phosphorylation of ROBO1 by ABL kinase
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ABL kinase (ABL1 or ABL2) phosphorylates the tyrosine residue Y1073 of the conserved CC1 motif (PTPYATT) in human ROBO1 (Bashaw et al. 2000).
Literature References
PubMed ID Title Journal Year
10892742 Repulsive axon guidance: Abelson and Enabled play opposing roles downstream of the roundabout receptor

Pawson, T, Bashaw, GJ, Goodman, CS, Kidd, T, Murray, D

Cell 2000
Participants
Input
Output
Participates
as an event of
Catalyst Activity

protein tyrosine kinase activity of SLIT2:ROBO1:ABL [plasma membrane]

Physical Entity
SLIT2:ROBO1:ABL [plasma membrane] (Homo sapiens)
Activity
protein tyrosine kinase activity (GO:0004713)
Orthologous Events
Phosphorylation of ROBO1 by ABL kinase (Bos taurus)
Phosphorylation of ROBO1 by ABL kinase (Drosophila melanogaster)
Phosphorylation of ROBO1 by ABL kinase (Mus musculus)
Authored
Garapati, P V  (2008-09-05)
Reviewed
Jaworski, A  (2017-07-31)
Kidd, T  (2009-08-18)
Created
Garapati, P V  (2009-07-11)
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