GLUT7 and GLUT11 transport glucose and fructose

Stable Identifier
R-HSA-428779
Type
Reaction [transition]
Species
Homo sapiens
Compartment
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SLC2A7 encodes GLUT7, a class II facilitative glucose transporter which was cloned from a human intestinal cDNA library (Li Q et al, 2004). It has a high affinity for glucose and fructose uptake. GLUT7 is found predominantly in the small intestine, colon, testis and prostate.

SLC2A11 encodes GLUT11 (Doege H et al, 2001), another member of the class II facilitative glucose transporters. It has the highest similarity with GLUT5 and in humans, three isoforms are expressed (GLUT11A-C) (Sasaki T et al, 2001). Human GLUT11 has been shown to transport glucose and fructose but not galactose when expressed in Xenopus oocytes ( Scheepers A et al, 2005).

Literature References
PubMed ID Title Journal Year
15033637 Cloning and functional characterization of the human GLUT7 isoform SLC2A7 from the small intestine

Li, Q, Manolescu, A, Ritzel, M, Yao, S, Slugoski, M, Young, JD, Chen, XZ, Cheeseman, CI

Am J Physiol Gastrointest Liver Physiol 2004
11583593 Characterization of human glucose transporter (GLUT) 11 (encoded by SLC2A11), a novel sugar-transport facilitator specifically expressed in heart and skeletal muscle

Doege, H, Bocianski, A, Scheepers, A, Axer, H, Eckel, J, Joost, HG, Schürmann, A

Biochem J 2001
16154905 Characterization of the human SLC2A11 (GLUT11) gene: alternative promoter usage, function, expression, and subcellular distribution of three isoforms, and lack of mouse orthologue

Scheepers, A, Schmidt, S, Manolescu, A, Cheeseman, CI, Bell, A, Zahn, C, Joost, HG, Schürmann, A

Mol Membr Biol 2005
11741323 Molecular cloning of a member of the facilitative glucose transporter gene family GLUT11 (SLC2A11) and identification of transcription variants

Sasaki, T, Minoshima, S, Shiohama, A, Shintani, A, Shimizu, A, Asakawa, S, Kawasaki, K, Shimizu, N

Biochem Biophys Res Commun 2001
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
sugar transmembrane transporter activity of GLUT7/11 [plasma membrane]
Physical Entity
Activity
Orthologous Events
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