Reactome | GLUT7 and GLUT11 transport glucose and fructose

GLUT7 and GLUT11 transport glucose and fructose

Stable Identifier

R-HSA-428779

Type

Reaction [transition]

Species

Homo sapiens

Compartment

plasma membrane

ReviewStatus

5/5

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GLUT7 and GLUT11 transport glucose and fructose

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SLC2A7 encodes GLUT7, a class II facilitative glucose transporter which was cloned from a human intestinal cDNA library (Li Q et al, 2004). It has a high affinity for glucose and fructose uptake. GLUT7 is found predominantly in the small intestine, colon, testis and prostate.

SLC2A11 encodes GLUT11 (Doege H et al, 2001), another member of the class II facilitative glucose transporters. It has the highest similarity with GLUT5 and in humans, three isoforms are expressed (GLUT11A-C) (Sasaki T et al, 2001). Human GLUT11 has been shown to transport glucose and fructose but not galactose when expressed in Xenopus oocytes ( Scheepers A et al, 2005).

Literature References

PubMed ID	Title	Journal	Year
11583593	Characterization of human glucose transporter (GLUT) 11 (encoded by SLC2A11), a novel sugar-transport facilitator specifically expressed in heart and skeletal muscle Doege, H, Bocianski, A, Joost, HG, Axer, H, Schürmann, A, Eckel, J, Scheepers, A	Biochem J	2001
15033637	Cloning and functional characterization of the human GLUT7 isoform SLC2A7 from the small intestine Li, Q, Manolescu, A, Slugoski, M, Cheeseman, CI, Chen, XZ, Young, JD, Yao, S, Ritzel, M	Am J Physiol Gastrointest Liver Physiol	2004
16154905	Characterization of the human SLC2A11 (GLUT11) gene: alternative promoter usage, function, expression, and subcellular distribution of three isoforms, and lack of mouse orthologue Manolescu, A, Joost, HG, Zahn, C, Schürmann, A, Bell, A, Cheeseman, CI, Schmidt, S, Scheepers, A	Mol Membr Biol	2005
11741323	Molecular cloning of a member of the facilitative glucose transporter gene family GLUT11 (SLC2A11) and identification of transcription variants Shintani, A, Minoshima, S, Sasaki, T, Asakawa, S, Shiohama, A, Shimizu, A, Kawasaki, K, Shimizu, N	Biochem Biophys Res Commun	2001