sphingosine 1-phosphate => phosphoethanolamine + hexadec-2-enal

Stable Identifier
R-HSA-428676
Type
Reaction [transition]
Species
Homo sapiens
Compartment
cytosol, endoplasmic reticulum membrane
Locations in the PathwayBrowser
Expand all
General
SVG | 
PNG
Low
Medium
High
 | PPTX  | SBGN
sphingosine 1-phosphate => phosphoethanolamine + hexadec-2-enal
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

SGPL1 (sphingosine-1-phosphate lyase 1), associated with the endoplasmic reticulum membrane, catalyzes the cleavage of cytosolic sphingosine 1-phosphate (S1P) to form phosphoethanolamine (PETA) and hexadec-2-enal (HD2NAL) (Van Veldhoven et al. 2000; Fyrst and Saba 2008).

Literature References
PubMed ID Title Journal Year
11018465 Human sphingosine-1-phosphate lyase: cDNA cloning, functional expression studies and mapping to chromosome 10q22(1)

Brys, V, Vermeesch, JR, Van Veldhoven, PP, Mannaerts, GP, Gijsbers, S

Biochim Biophys Acta 2000
18558101 Sphingosine-1-phosphate lyase in development and disease: sphingolipid metabolism takes flight

Fyrst, H, Saba, JD

Biochim Biophys Acta 2008
Participants
Input
Output
Participates
as an event of
Catalyst Activity

sphinganine-1-phosphate aldolase activity of PXLP-SGPL1 [endoplasmic reticulum membrane]

Physical Entity
PXLP-SGPL1 [endoplasmic reticulum membrane] (Homo sapiens)
Activity
sphinganine-1-phosphate aldolase activity (GO:0008117)
Orthologous Events
sphingosine 1-phosphate => phosphoethanolamine + hexadec-2-enal (Bos taurus)
sphingosine 1-phosphate => phosphoethanolamine + hexadec-2-enal (Caenorhabditis elegans)
sphingosine 1-phosphate => phosphoethanolamine + hexadec-2-enal (Canis familiaris)
sphingosine 1-phosphate => phosphoethanolamine + hexadec-2-enal (Danio rerio)
sphingosine 1-phosphate => phosphoethanolamine + hexadec-2-enal (Dictyostelium discoideum)
sphingosine 1-phosphate => phosphoethanolamine + hexadec-2-enal (Drosophila melanogaster)
sphingosine 1-phosphate => phosphoethanolamine + hexadec-2-enal (Gallus gallus)
sphingosine 1-phosphate => phosphoethanolamine + hexadec-2-enal (Mus musculus)
sphingosine 1-phosphate => phosphoethanolamine + hexadec-2-enal (Rattus norvegicus)
sphingosine 1-phosphate => phosphoethanolamine + hexadec-2-enal (Saccharomyces cerevisiae)
sphingosine 1-phosphate => phosphoethanolamine + hexadec-2-enal (Sus scrofa)
sphingosine 1-phosphate => phosphoethanolamine + hexadec-2-enal (Xenopus tropicalis)
Cross References
Rhea
Authored
D'Eustachio, P  (2009-08-21)
Reviewed
Luberto, C  (2009-11-19)
Hannun, YA  (2009-11-19)
Jassal, B  (2009-08-21)
Created
D'Eustachio, P  (2009-07-07)
Cite Us!