sphingosine 1-phosphate => phosphoethanolamine + hexadec-2-enal

Stable Identifier
R-HSA-428676
Type
Reaction [transition]
Species
Homo sapiens
Compartment
cytosol, endoplasmic reticulum membrane
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sphingosine 1-phosphate => phosphoethanolamine + hexadec-2-enal
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SGPL1 (sphingosine-1-phosphate lyase 1), associated with the endoplasmic reticulum membrane, catalyzes the cleavage of cytosolic sphingosine 1-phosphate (S1P) to form phosphoethanolamine (PETA) and hexadec-2-enal (HD2NAL) (Van Veldhoven et al. 2000; Fyrst and Saba 2008).

Literature References
PubMed ID Title Journal Year
18558101 Sphingosine-1-phosphate lyase in development and disease: sphingolipid metabolism takes flight

Fyrst, H, Saba, JD

Biochim Biophys Acta 2008
11018465 Human sphingosine-1-phosphate lyase: cDNA cloning, functional expression studies and mapping to chromosome 10q22(1)

Van Veldhoven, PP, Gijsbers, S, Mannaerts, GP, Vermeesch, JR, Brys, V

Biochim Biophys Acta 2000
Participants
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Output
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as an event of
Catalyst Activity

sphinganine-1-phosphate aldolase activity of PXLP-SGPL1 [endoplasmic reticulum membrane]

Physical Entity
PXLP-SGPL1 [endoplasmic reticulum membrane] (Homo sapiens)
Activity
sphinganine-1-phosphate aldolase activity (GO:0008117)
Orthologous Events
sphingosine 1-phosphate => phosphoethanolamine + hexadec-2-enal (Bos taurus)
sphingosine 1-phosphate => phosphoethanolamine + hexadec-2-enal (Caenorhabditis elegans)
sphingosine 1-phosphate => phosphoethanolamine + hexadec-2-enal (Canis familiaris)
sphingosine 1-phosphate => phosphoethanolamine + hexadec-2-enal (Danio rerio)
sphingosine 1-phosphate => phosphoethanolamine + hexadec-2-enal (Dictyostelium discoideum)
sphingosine 1-phosphate => phosphoethanolamine + hexadec-2-enal (Drosophila melanogaster)
sphingosine 1-phosphate => phosphoethanolamine + hexadec-2-enal (Mus musculus)
sphingosine 1-phosphate => phosphoethanolamine + hexadec-2-enal (Rattus norvegicus)
sphingosine 1-phosphate => phosphoethanolamine + hexadec-2-enal (Saccharomyces cerevisiae)
sphingosine 1-phosphate => phosphoethanolamine + hexadec-2-enal (Sus scrofa)
sphingosine 1-phosphate => phosphoethanolamine + hexadec-2-enal (Xenopus tropicalis)
Cross References
Rhea
Authored
D'Eustachio, P  (2009-08-21)
Reviewed
Hannun, YA  (2009-11-19)
Luberto, C  (2009-11-19)
Jassal, B  (2009-08-21)
Created
D'Eustachio, P  (2009-07-07)
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