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PXLP-SGPL1 [endoplasmic reticulum membrane]
Stable Identifier
R-HSA-428661
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
endoplasmic reticulum membrane
Synonyms
SGPL1, sphingosine-1-phosphate lyase 1
Locations in the PathwayBrowser for interactor UniProt:Q53HI1 UNC50
Expand all
Metabolism (Homo sapiens)
Metabolism of lipids (Homo sapiens)
Sphingolipid metabolism (Homo sapiens)
Sphingolipid catabolism (Homo sapiens)
PXLP-SGPL1 cleaves sphingoid-1-phosphates (Homo sapiens)
PXLP-SGPL1 [endoplasmic reticulum membrane] (Homo sapiens)
External Reference Information
External Reference
UniProt:O95470 SGPL1
Gene Names
SGPL1, KIAA1252
Chain
chain:1-568
Reference Genes
BioGPS Gene:8879 SGPL1
COSMIC (genes):SGPL1 SGPL1
CTD Gene:8879 SGPL1
dbSNP Gene:8879 SGPL1
ENSEMBL:ENSG00000166224 SGPL1
ENSEMBL_homo_sapiens_GENE:ENSG00000166224.18 SGPL1
HGNC:10817 SGPL1
KEGG Gene (Homo sapiens):8879 SGPL1
Monarch:8879 SGPL1
NCBI Gene:8879 SGPL1
OMIM:603729 SGPL1
UCSC:O95470 SGPL1
Reference Transcript
RefSeq:XM_011540316.2 SGPL1
RefSeq:XM_005270263.1 SGPL1
RefSeq:XM_011540317.1 SGPL1
RefSeq:NM_003901.3 SGPL1
Other Identifiers
11719958_at
11719959_at
16705778
208381_PM_s_at
208381_s_at
212321_PM_at
212321_at
212322_PM_at
212322_at
3250864
3250865
3250866
3250867
3250871
3250873
3250874
3250875
3250876
3250877
3250883
3250885
3250887
3250888
3250890
3250892
3250893
3250896
3250897
3250898
3250899
35875_at
35876_s_at
44046_at
63400_at
7928171
8879
A_14_P106979
A_14_P125528
A_14_P126970
A_14_P127175
A_23_P75325
A_24_P940815
A_33_P3327847
GE62800
GE80468
GO:0001553
GO:0001570
GO:0001822
GO:0003824
GO:0005515
GO:0005783
GO:0005789
GO:0006629
GO:0006631
GO:0006665
GO:0006672
GO:0006807
GO:0006915
GO:0007283
GO:0008117
GO:0008209
GO:0008210
GO:0008585
GO:0009791
GO:0010761
GO:0012501
GO:0016020
GO:0016829
GO:0016830
GO:0019752
GO:0022414
GO:0023052
GO:0030097
GO:0030149
GO:0030154
GO:0030170
GO:0033327
GO:0040014
GO:0043226
GO:0048008
GO:0048705
GO:0048856
GO:0048870
GO:0060021
GO:0060325
GO:0097190
HMNXSV003040056
Hs.186613.1.S2_3p_at
Hs.186613.1.S3_3p_at
ILMN_1761531
PH_hs_0010928
TC10000434.hg
TC10002114.hg
g10190652_3p_a_at
Inferred To
spl-1 [endoplasmic reticulum membrane]
(Caenorhabditis elegans)
DPL1 [endoplasmic reticulum membrane]
(Saccharomyces cerevisiae)
PXLP-SGPL1 [endoplasmic reticulum membrane]
(Gallus gallus)
SGPL1 [endoplasmic reticulum membrane]
(Bos taurus)
SGPL1 [endoplasmic reticulum membrane]
(Canis familiaris)
SGPL1 [endoplasmic reticulum membrane]
(Sus scrofa)
Sply [endoplasmic reticulum membrane]
(Drosophila melanogaster)
sgpl1 [endoplasmic reticulum membrane]
(Xenopus tropicalis)
Sgpl1 [endoplasmic reticulum membrane]
(Mus musculus)
Sgpl1 [endoplasmic reticulum membrane]
(Rattus norvegicus)
sglA [endoplasmic reticulum membrane]
(Dictyostelium discoideum)
Modified Residues
Name
N6-pyridoxal phosphate-L-lysine at 353
Coordinate
353
PsiMod Name
N6-pyridoxal phosphate-L-lysine [MOD:00128]
PsiMod Definition
A protein modification that effectively converts an L-lysine residue to N6-pyridoxal phosphate-L-lysine.
Cross References
RefSeq
NP_003892.2
,
XP_011538619.1
,
XP_005270320.1
,
XP_011538618.1
Guide to Pharmacology - Targets
2522
OpenTargets
ENSG00000166224
ZINC - Substances
SGPL1_HUMAN
ZINC target
O95470
PRO
O95470
PDB
4Q6R
,
8AYF
IntEnz
4.1.2.27
GeneCards
O95470
HPA
ENSG00000166224-SGPL1
Ensembl
ENST00000697931
,
ENST00000373202
,
ENSP00000513482
,
ENST00000697932
,
ENSG00000166224
,
ENST00000697928
,
ENSP00000513485
,
ENSP00000362298
,
ENSP00000513486
Pharos - Targets
O95470
Orphanet
25622
ZINC - Predictions - Purchasable
SGPL1_HUMAN
HMDB Protein
HMDBP01052
Interactors (46)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q9NX47 MARH5
0.556
3
UniProt:Q8TAC9 SCAM5
0.556
3
UniProt:Q8NHW4 CCL4L1
1
CCL4L1 [extracellular region]
(R-HSA-8865389)
0.556
3
UniProt:Q96HP8 T176A
0.556
3
UniProt:Q04941 PLP2
0.556
3
UniProt:Q14802-3 FXYD3
0.556
3
UniProt:Q92482 AQP3
1
AQP3 [plasma membrane]
(R-HSA-431723)
0.556
3
UniProt:Q12846 STX4
4
STX4 [phagocytic vesicle membrane]
(R-HSA-2029044)
STX4 [plasma membrane]
(R-HSA-181519)
STX4 [cytosol]
(R-HSA-114505)
p-STX4 [cytosol]
(R-HSA-114681)
0.556
3
UniProt:P30519 HMOX2
3
HMOX2 [plasma membrane]
(R-HSA-6799676)
HMOX2 [specific granule membrane]
(R-HSA-6799628)
HMOX2 [endoplasmic reticulum membrane]
(R-HSA-189391)
0.556
3
UniProt:Q5GAN6 RNS10
0.556
3
UniProt:O43315 AQP9
1
AQP9 [plasma membrane]
(R-HSA-431761)
0.556
3
UniProt:Q53HI1 UNC50
0.556
3
UniProt:Q92843 B2CL2
0.556
3
UniProt:A5PKU2 A5PKU2
0.556
3
UniProt:O14817 TSN4
0.556
3
UniProt:Q9UKR5 ERG28
0.556
3
UniProt:Q5QGT7 RTP2
2
RTP2 [endoplasmic reticulum membrane]
(R-HSA-9752982)
RTP2 [plasma membrane]
(R-HSA-8939446)
0.556
3
UniProt:Q5BJF2 SGMR2
0.556
3
UniProt:Q6PL45-2 BRICD5
0.556
3
UniProt:Q99726 SLC30A3
1
SLC30A3 [synaptic vesicle membrane]
(R-HSA-437087)
0.556
3
UniProt:Q01628 IFITM3
1
IFITM3 [plasma membrane]
(R-HSA-1015688)
0.556
3
UniProt:P02808 STAT
0.556
3
UniProt:Q9NWH2 TM242
0.556
3
UniProt:Q5VZY2 PLPP4
1
PPAPDC1A [plasma membrane]
(R-HSA-2029082)
0.556
3
UniProt:P30301 MIP
1
MIP [plasma membrane]
(R-HSA-432026)
0.556
3
UniProt:P52803 EFNA5
3
EFNA5 (21-?) N-ter [extracellular region]
(R-HSA-3928456)
EFNA5 (?-203) C-ter [plasma membrane]
(R-HSA-3928431)
EFNA5 [plasma membrane]
(R-HSA-2682331)
0.556
3
UniProt:Q9UNK0 STX8
0.556
3
UniProt:Q7L5A8 FA2H
1
FA2H [endoplasmic reticulum membrane]
(R-HSA-5693771)
0.556
3
UniProt:Q8N128-2 FAM177A1
0.556
3
UniProt:Q6ZSS7 MFSD6
0.556
3
UniProt:Q9NXK6 PAQR5
0.556
3
UniProt:Q8IY49-2 MMD2
0.556
3
UniProt:Q8N6F1-2 CLDN19
0.556
3
UniProt:Q9UF02 CCG5
0.527
2
UniProt:Q9H813 PACC1
0.527
2
UniProt:Q14627 IL13RA2
1
IL13RA2 [extracellular region]
(R-HSA-449666)
0.527
2
UniProt:O14498 ISLR
2
ISLR [extracellular region]
(R-HSA-8848919)
ISLR [platelet alpha granule lumen]
(R-HSA-8848912)
0.527
3
UniProt:Q8WWF5 ZNRF4
0.527
2
UniProt:P33151 CDH5
2
p-S665-VE-cadherin [plasma membrane]
(R-HSA-5357435)
VE-cadherin [plasma membrane]
(R-HSA-418992)
0.527
2
UniProt:Q7KYR7 BTN2A1
1
BTN2A1 [plasma membrane]
(R-HSA-8851994)
0.527
2
UniProt:O75326 SEMA7A
1
SEMA7A [plasma membrane]
(R-HSA-198229)
0.527
2
UniProt:Q8IXB3 TARG1
0.527
2
UniProt:Q13503 MED21
1
MED21 [nucleoplasm]
(R-HSA-212456)
0.527
2
UniProt:P51575 P2RX1
3
P2RX1 [specific granule membrane]
(R-HSA-6803317)
P2RX1 [plasma membrane]
(R-HSA-61129)
P2RX1 [secretory granule membrane]
(R-HSA-6803326)
0.527
2
UniProt:Q9Y279 VSIG4
0.527
2
UniProt:Q86WV6 STING1
5
TMEM173 [plasma membrane]
(R-HSA-6804815)
TMEM173 [secretory granule membrane]
(R-HSA-6804798)
K63polyUb-STING [endoplasmic reticulum membrane]
(R-HSA-3134805)
K63polyUb-STING [cytoplasmic vesicle membrane]
(R-HSA-3248021)
STING [endoplasmic reticulum membrane]
(R-HSA-1834940)
0.499
2
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