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Proton-coupled neutral amino acid transporters
Stable Identifier
R-HSA-428559
Type
Pathway
Species
Homo sapiens
ReviewStatus
5/5
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Transport of small molecules (Homo sapiens)
SLC-mediated transmembrane transport (Homo sapiens)
Transport of inorganic cations/anions and amino acids/oligopeptides (Homo sapiens)
Proton-coupled neutral amino acid transporters (Homo sapiens)
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The human SLC36A gene family encodes four proton-coupled neutral amino acid transporters, PAT1-4. PAT1 and 2 mediate electroneutral symport of protons and small neutral amino acids like glycine, alanine and proline. PAT3 and 4 are orphans with unknown function (Boll M et al, 2004).
Literature References
PubMed ID
Title
Journal
Year
12748860
The SLC36 family: proton-coupled transporters for the absorption of selected amino acids from extracellular and intracellular proteolysis
Boll, M
,
Daniel, H
,
Gasnier, B
Pflugers Arch
2004
Participants
Events
SLC36A1-mediated uptake of glycine, proline, and alanine
(Homo sapiens)
SLC36A2 cotransports Gly, L-Pro with H+ from extracellular region to cytosol
(Homo sapiens)
Participates
as an event of
Transport of inorganic cations/anions and amino acids/oligopeptides (Homo sapiens)
Orthologous Events
Proton-coupled neutral amino acid transporters (Bos taurus)
Proton-coupled neutral amino acid transporters (Caenorhabditis elegans)
Proton-coupled neutral amino acid transporters (Canis familiaris)
Proton-coupled neutral amino acid transporters (Dictyostelium discoideum)
Proton-coupled neutral amino acid transporters (Drosophila melanogaster)
Proton-coupled neutral amino acid transporters (Gallus gallus)
Proton-coupled neutral amino acid transporters (Mus musculus)
Proton-coupled neutral amino acid transporters (Rattus norvegicus)
Proton-coupled neutral amino acid transporters (Saccharomyces cerevisiae)
Proton-coupled neutral amino acid transporters (Sus scrofa)
Proton-coupled neutral amino acid transporters (Xenopus tropicalis)
Authored
Jassal, B (2009-07-06)
Reviewed
He, L (2009-08-24)
Created
Jassal, B (2009-07-06)
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