Reactome | Glypican-1 (GPC1) binds SLIT2

Glypican-1 (GPC1) binds SLIT2

Stable Identifier

R-HSA-428518

Type

Reaction [binding]

Species

Homo sapiens

Compartment

plasma membrane

ReviewStatus

5/5

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SLIT2 and both its natural cleavage products bind glypican-1 (GPC1), a glycosyl phosphatidyl inositol (GPI) anchored heparan sulfate proteoglycan (HSPG), through its C-terminus. Besides glypican-1, other HSPG may also be involved in SLIT2 binding. GPC1:HSPG is important for high affinity binding of SLIT to its receptor and for the repulsive activity of SLIT. SLIT-ROBO signaling strictly requires binding to heparan sulfate. HSPGs may also modulate the extracellular distribution or stability of SLIT proteins (Ronca et al. 2001, Zhang et al. 2004).

Literature References

PubMed ID	Title	Journal	Year
11375980	Characterization of Slit protein interactions with glypican-1 Ronca, F, Andersen, JS, Paech, V, Margolis, RU	J Biol Chem	2001
15063764	Structural determinants of heparan sulfate interactions with Slit proteins Zhang, F, Ronca, F, Linhardt, RJ, Margolis, RU	Biochem Biophys Res Commun	2004