Recruitment of SOS to plasma membrane

Stable Identifier
R-HSA-428515
Type
Reaction [binding]
Species
Homo sapiens
Compartment
cytosol, plasma membrane
ReviewStatus
5/5
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Recruitment of SOS to plasma membrane
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Upon SLIT-mediated ROBO stimulation, SOS1 or SOS2 is recruited into the multiprotein complex consisting of SLIT2, ROBO1 and the SH3-SH2 protein NCK1 or NCK2 (orthologues of Drosophila Dock). NCK bridges the physical association between ROBO and SOS. This interaction was demonstrated in both Drosophila and human cells (Hu et al. 1995, Fritz et al. 2000, Yang and Bashaw 2006).

Participants
Input
Output
Participates
as an event of
Inferred From
Recruitment of Sos to plasma membrane (Drosophila melanogaster)
Authored
Garapati, P V  (2008-09-05)
Reviewed
Jaworski, A  (2017-07-31)
Kidd, T  (2009-08-18)
Created
Garapati, P V  (2009-07-06)
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