Reactome | DEGS2 oxygenates dihydroceramide

DEGS2 oxygenates dihydroceramide

Stable Identifier

R-HSA-428260

Type

Reaction [transition]

Species

Homo sapiens

Compartment

cytosol, endoplasmic reticulum membrane

Synonyms

dihydroceramide + Fe2+ + H+ + O2 => phytoceramide + Fe3+ + H2O

ReviewStatus

5/5

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DEGS2 (sphingolipid C4-hydroxylase 2 / “degenerative spermatocyte homolog 2”) enzyme associated with the cytosolic face of the endoplasmic reticulum catalyzes the hydroxylation of dihydroceramide to form phytoceramide (Mizutani et al. 2004). DEGS2 appears not to be essential, with another unknown enzyme catalyzing the same reaction. The highest activity of DEGS2 is on long-chain (>= C21) dihydroceramides. DEGS2 also catalyzes the C4-dehydrogenation of dihydroceramide, but this activity is minor (Ota et al., 2023).

Literature References

PubMed ID	Title	Journal	Year
15063729	Identification of the human sphingolipid C4-hydroxylase, hDES2, and its up-regulation during keratinocyte differentiation Mizutani, Y, Kihara, A, Igarashi, Y	FEBS Lett	2004
36907437	Bifunctional DEGS2 has higher hydroxylase activity toward substrates with very-long-chain fatty acids in the production of phytosphingosine ceramides Ota, A, Morita, H, Naganuma, T, Miyamoto, M, Jojima, K, Nojiri, K, Matsuda, J, Kihara, A	J Biol Chem	2023