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SPHK2 [cytosol]
Stable Identifier
R-HSA-428236
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
cytosol
Synonyms
sphingosine kinase 2
Locations in the PathwayBrowser
Expand all
Metabolism (Homo sapiens)
Metabolism of lipids (Homo sapiens)
Sphingolipid metabolism (Homo sapiens)
Sphingolipid de novo biosynthesis (Homo sapiens)
SPHK2 binds SPHK2 inhibitors (Homo sapiens)
SPHK2 [cytosol] (Homo sapiens)
SPHK2:SPHK2 inhibitors [cytosol] (Homo sapiens)
SPHK2 [cytosol] (Homo sapiens)
SPHK2 phosphorylates sphingoid (Homo sapiens)
SPHK2 [cytosol] (Homo sapiens)
SPHK2:SPHK2 inhibitors [cytosol] (Homo sapiens)
SPHK2 [cytosol] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q9NRA0 SPHK2
Gene Names
SPHK2, SK2
Chain
chain:1-654
Reference Genes
BioGPS Gene:56848 SPHK2
COSMIC (genes):SPHK2 SPHK2
CTD Gene:56848 SPHK2
dbSNP Gene:56848 SPHK2
ENSEMBL:ENSG00000063176 SPHK2
HGNC:18859 SPHK2
KEGG:hsa:56848 SPHK2
Monarch:56848 SPHK2
NCBI Gene:56848 SPHK2
OMIM:607092 SPHK2
UCSC:Q9NRA0 SPHK2
Reference Transcript
RefSeq:NM_020126.4 SPHK2
RefSeq:NM_001204160.2 SPHK2
RefSeq:XM_011527133.1 SPHK2
RefSeq:NM_001204159.2 SPHK2
RefSeq:XM_006723292.1 SPHK2
RefSeq:NM_001204158.2 SPHK2
RefSeq:XM_011527134.1 SPHK2
Other Identifiers
11723662_a_at
11749160_a_at
11749161_x_at
11760800_at
11760801_x_at
11761171_x_at
16863834
209857_PM_s_at
209857_s_at
3837896
3837897
3837899
3837900
3837902
3837903
3837904
3837905
3837906
3837907
3837908
3837909
3837910
3837911
3837912
3837913
3837914
3837915
3837916
3837917
3837918
3837919
3837920
3837921
3837922
3837923
3837924
3837925
3837926
3837927
3837928
3837929
3837930
3837931
40273_PM_at
40273_at
4920241C_3p_s_at
56848
8030078
88521_at
A_14_P101222
A_23_P303181
A_33_P3332666
GE82496
GE88421
GO:0000786
GO:0001568
GO:0001727
GO:0002720
GO:0003376
GO:0003824
GO:0005515
GO:0005524
GO:0005634
GO:0005654
GO:0005737
GO:0005739
GO:0005743
GO:0005764
GO:0005765
GO:0005773
GO:0005783
GO:0005829
GO:0006325
GO:0006629
GO:0006669
GO:0006670
GO:0007420
GO:0008283
GO:0008284
GO:0008481
GO:0016020
GO:0016301
GO:0016740
GO:0017050
GO:0030148
GO:0030308
GO:0031267
GO:0032736
GO:0032755
GO:0032760
GO:0033008
GO:0038036
GO:0042393
GO:0043065
GO:0043122
GO:0043226
GO:0043231
GO:0043306
GO:0045815
GO:0046512
GO:0048856
GO:0060089
GO:0090037
GO:0090280
GO:1903426
GO:1904628
GO:1904959
GO:2000304
GO:2001169
HMNXSV003037646
ILMN_1729281
PH_hs_0025969
TC19000707.hg
g8248284_3p_s_at
Participates
as an input of
SPHK2 binds SPHK2 inhibitors (Homo sapiens)
as a component of
SPHK2:SPHK2 inhibitors [cytosol] (Homo sapiens)
Inferred To
Sk2 [cytosol]
(Drosophila melanogaster)
sphk2 [cytosol]
(Xenopus tropicalis)
sgkD [cytosol]
(Dictyostelium discoideum)
SPHK2 [cytosol]
(Bos taurus)
SPHK2 [cytosol]
(Caenorhabditis elegans)
SPHK2 [cytosol]
(Canis familiaris)
SPHK2 [cytosol]
(Dictyostelium discoideum)
SPHK2 [cytosol]
(Mus musculus)
SPHK2 [cytosol]
(Rattus norvegicus)
SPHK2 [cytosol]
(Saccharomyces cerevisiae)
SPHK2 [cytosol]
(Schizosaccharomyces pombe)
SPHK2 [cytosol]
(Sus scrofa)
sgkC [cytosol]
(Dictyostelium discoideum)
tim54 [cytosol]
(Schizosaccharomyces pombe)
Homologues of SPHK2 [cytosol]
(Dictyostelium discoideum)
Homologues of SPHK2 [cytosol]
(Drosophila melanogaster)
Homologues of SPHK2 [cytosol]
(Saccharomyces cerevisiae)
Homologues of SPHK2 [cytosol]
(Schizosaccharomyces pombe)
TIM54 [cytosol]
(Saccharomyces cerevisiae)
Sk1 [cytosol]
(Drosophila melanogaster)
Cross References
Guide to Pharmacology - Targets
2205
ENSEMBL
ENST00000598088
,
ENSP00000469158
,
ENSP00000471205
,
ENST00000600537
,
ENSG00000063176
,
ENST00000245222
,
ENSP00000245222
,
ENST00000599748
,
ENSP00000470092
OpenTargets
ENSG00000063176
ZINC - Substances
SPHK2_HUMAN
ZINC - Biogenic
SPHK2_HUMAN
ZINC target
Q9NRA0
PRO
Q9NRA0
ZINC - Investigational
SPHK2_HUMAN
ZINC - Metabolites
SPHK2_HUMAN
IntEnz
2.7.1.91
GeneCards
SPHK2
HPA
ENSG00000063176-SPHK2
Pharos - Targets
Q9NRA0
ZINC - Predictions - Purchasable
SPHK2_HUMAN
HMDB Protein
HMDBP01083
Interactors (1)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q96CV9 OPTN
6
p-S177,S473,S513-OPTN [cytosol]
(R-HSA-9687840)
OPTN [cytosol]
(R-HSA-9687907)
p-S177-OPTN [cytosol]
(R-HSA-2562525)
p-S177-OPTN [nucleoplasm]
(R-HSA-2562595)
OPTN [Golgi membrane]
(R-HSA-2161111)
OPTN [recycling endosome membrane]
(R-HSA-8854141)
0.556
3
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