sphinganine (dihydrosphingosine) +ATP => sphinganine 1-phosphate + ADP

Stable Identifier
Reaction [transition]
Homo sapiens
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SPHK1 and 2 (sphingosine kinases 1 and 2) each catalyze the reaction of sphinganine (dihydrosphingosine) and ATP to form dihydrosphingosine 1-phosphate and ADP. Both enzymes are found in the cytosol (although they are also present in membrane-associated forms). Both enzymes also catalyze the phosphorylation of sphingosine to sphingosine 1-phosphate (S1P) (Liu et al. 2000, Nava et al. 2000, Pitson et al. 2000).

Literature References
PubMed ID Title Journal Year
10802064 Functional characterization of human sphingosine kinase-1

Sugiura, M, Poulton, S, Liu, H, Nava, VE, Spiegel, S, Kohama, T, Milstien, S, Kono, K, Lacana, E

FEBS Lett 2000
10751414 Molecular cloning and functional characterization of a novel mammalian sphingosine kinase type 2 isoform

Sugiura, M, Edsall, LC, Poulton, S, Nava, VE, Liu, H, Spiegel, S, Kohama, T, Milstien, S, Kono, K

J Biol Chem 2000
10947957 Human sphingosine kinase: purification, molecular cloning and characterization of the native and recombinant enzymes

D'Andrea, RJ, Pitson, SM, Gamble, JR, Vadas, MA, Wattenberg, BW, Moretti, PA, Vandeleur, L, Xia, P

Biochem J 2000
Catalyst Activity

sphinganine kinase activity of SPHK [cytosol]

Orthologous Events
Cross References
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